Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Jacksonville Bus Station | Gateway Station | Cheapest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Jacksonville Bus Station | Gateway Station | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Jacksonville Bus Station | Gateway Station | No tags |
Last refresh of the prices: Yesterday at 12:18 PM EST.
Compare 2 ways to travel from Jacksonville to St. Louis
Among the sustainable travel choices, the Bus stands out as a good way to reach St. Louis. The journey takes about 1 day, 40 minutes and with fares starting at just R 2 301, it presents an excellent value for a comfortable ride.
Where are the popular stops in Jacksonville and St. Louis?
Stops in Jacksonville
- A3570 Clifford Ln, Jacksonville, FL 32209, USA
- B
W Forsyth St
1111 W Forsyth St, Jacksonville, FL 32204, USA - C
Kings Avenue Station
1003 Kings Avenue, Jacksonville, FL 32207 - D
JRTC Greyhound Bus Station
111 W. Forsyth St, Jacksonville, FL 32202, USA
Compare bus companies
Frequently asked questions about travelling from Jacksonville, FL to St. Louis by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Jacksonville to St. Louis?
The cheapest bus tickets from Jacksonville to St. Louis start at R 2 301. The average price for this route is around R 3 113. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Jacksonville to St. Louis?
The average bus journey time from Jacksonville to St. Louis is 1d , covering a distance of 1208 km. The fastest bus gets you there in 19h 30m and is operated by FlixBus.
Which bus companies service the Jacksonville to St. Louis route?
What is the earliest and latest departure time for the bus from Jacksonville to St. Louis?
The earliest bus departs from Jacksonville to St. Louis at 09:30. And the latest bus departs at 22:05.
What are the CO₂ emissions for the bus trip from Jacksonville to St. Louis?
A bus trip from Jacksonville to St. Louis produces an estimated 30 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
What is the best bus company from Jacksonville to St. Louis?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87463 reviews.
Which bus company has the best Wi-Fi from Jacksonville to St. Louis?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company offers the most punctual service from Jacksonville to St. Louis?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Jacksonville to St. Louis?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Jacksonville, FL to St. Louis was searched and found on 12 Jan 2026 with a price of R 2 189To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Jacksonville, FL to St. Louis as early as possible.
You can expect to pay from R 2 189 to R 2 417 for a bus ticket from Jacksonville, FL to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at R 2 189, which is on 2026-01-12.
What's the cheapest way to go from Jacksonville, FL to St. Louis?
The Bus is the cheapest travel choice for this destination
