Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Knoxville Bus Station | Indianapolis Bus Station | CheapestFastest | ||||
| Bus | Knoxville Bus Station | Indianapolis Bus Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Knoxville Bus Station | Downtown Transit Center | No tags |
Last refresh of the prices: Today at 12:51 AM EST.
Get from Knoxville to Indianapolis
The journey takes about 14 hours 15 minutes, and with fares starting at just R 1 524, it presents an excellent value for a comfortable ride.
Where are the popular stops in Knoxville and Indianapolis?
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Stops in Indianapolis
- A350 S Illinois St, Indianapolis, IN 46225
Compare bus companies
Based on 87493 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. Greyhound ticket prices on this trip start at R 1 524
Greyhound Knoxville Indianapolis recent customer reviews
Was a nice experience, will go greyhound again
Kimberly L.
Frequently asked questions about travelling from Knoxville, TN to Indianapolis by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Knoxville to Indianapolis?
The cheapest bus tickets from Knoxville to Indianapolis start at R 1 524. The average price for this route is around R 2 521. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Knoxville to Indianapolis?
The average bus journey time from Knoxville to Indianapolis is 14h 15m, covering a distance of 465 km. The fastest bus gets you there in 10h 35m and is operated by Greyhound.
Which bus companies service the Knoxville to Indianapolis route?
Several major bus companies operate on this route with 3 buses available per day.
What is the earliest and latest departure time for the bus from Knoxville to Indianapolis?
The earliest bus departs from Knoxville to Indianapolis at 18:10. And the latest bus departs at 19:40.
What are the CO₂ emissions for the bus trip from Knoxville to Indianapolis?
A bus trip from Knoxville to Indianapolis produces an estimated 12 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville, TN to Indianapolis was searched and found on 10 Jan 2026 with a price of R 1 893To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Indianapolis as early as possible.
You can expect to pay from R 1 893 to R 2 434 for a bus ticket from Knoxville, TN to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at R 2 214, which is on 2026-01-12.
