Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Knoxville Bus Station | Indianapolis Bus Station | Cheapest | ||||
| Bus | Knoxville Bus Station | Indianapolis Bus Station | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Knoxville Bus Station | Downtown Transit Center | No tags |
Last refresh of the prices: Yesterday at 7:12 AM EST.
Get from Knoxville to Indianapolis
The journey takes about 14 hours 15 minutes, and with fares starting at just R 1 180, it presents an excellent value for a comfortable ride.
Where are the popular stops in Knoxville and Indianapolis?
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Compare bus companies
Based on 87397 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. Greyhound ticket prices on this trip start at R 1 180
Greyhound Knoxville Indianapolis recent customer reviews
Was a nice experience, will go greyhound again
Kimberly L.
Frequently asked questions about travelling from Knoxville, TN to Indianapolis by bus
How much does a bus ticket from Knoxville to Indianapolis cost?
The bus ticket price from Knoxville to Indianapolis starts at R 1 180. The best way to find cheap bus tickets from Knoxville to Indianapolis is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the bus ride from Knoxville to Indianapolis?
The average travel time between Knoxville and Indianapolis is around 14h 15m, although the fastest bus will take about 9h 35m. This is the time it takes to travel the 468 km that separates the two cities.
How many daily bus connections are there between Knoxville and Indianapolis?
The number of buses from Knoxville to Indianapolis can differ depending on the day of the week. On average, there are 3 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Knoxville to Indianapolis by comparing and selecting the bus that fits your travel style and budget on Busbud.
Which bus companies travel from Knoxville to Indianapolis?
When taking the bus from Knoxville to Indianapolis, you can travel comfortably and safely with Greyhound.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville, TN to Indianapolis was searched and found on 24 Nov 2025 with a price of R 1 859To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Indianapolis as early as possible.
You can expect to pay from R 1 859 to R 4 157 for a bus ticket from Knoxville, TN to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at R 2 079, which is on 2025-11-28.
