Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound | Bus | Knoxville Bus Station | Downtown Transit Center | No tags | ||||
 | Bus | Knoxville Bus Station | Indianapolis Bus Station | No tags | ||||
Greyhound + FlixBus | Bus | Knoxville Bus Station | Downtown Transit Center | No tags | ||||
| Bus | Knoxville Bus Station | Indianapolis Bus Station | No tags | ||||
FlixBus + Greyhound | Bus | Knoxville Bus Station | Downtown Transit Center | No tags |
Get from Knoxville to Indianapolis
The journey takes about 14 hours 15 minutes and with fares starting at just $91, it presents an excellent value for a comfortable ride.
Where are the popular stops in Knoxville and Indianapolis?
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Knoxville Indianapolis recent customer reviews
Was a nice experience, will go greyhound again
Kimberly L.
Frequently asked questions about traveling from Knoxville, TN to Indianapolis by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Knoxville to Indianapolis?
The cheapest bus tickets from Knoxville to Indianapolis start from $91. The average price for this route is around $147. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Knoxville to Indianapolis?
The average bus trip duration from Knoxville to Indianapolis is 14h 15m, covering a distance of 288 miles (465 km). The quickest bus can get you there in 10h 35m and is operated by Greyhound.
Which bus companies service the Knoxville to Indianapolis route?
Several major train operators operate on this route with 2 trains available per day.
What is the earliest and latest departure time for the bus from Knoxville to Indianapolis?
The earliest bus departs from Knoxville to Indianapolis at 6:10pm. And the latest bus departs at 7:05pm.
What are the CO₂ emissions for the bus trip from Knoxville to Indianapolis?
A bus trip from Knoxville to Indianapolis generates an estimated 12 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville, TN to Indianapolis was searched and found on Jan 4, 2026 with a price of $110To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Indianapolis, as early as possible.
You can expect to pay from $110 to $111 for a bus ticket from Knoxville, TN to Indianapolis based on the last 0 days. You can expect to find the cheapest price for the trip at $110 which is on 2026-01-04.
