Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Terminal Bus Palermo | Syracuse bus station | Cheapest | ||||
| Bus | Palermo Oreto Orsi | Syracuse bus station | Fastest | ||||
| Bus | Terminal Bus Palermo | Syracuse bus station | No tags | ||||
 | Bus | Terminal Bus Palermo | Terminal Interbus | No tags | ||||
| Bus | Terminal Bus Palermo | Syracuse bus station | No tags |
Last refresh of the prices: Today at 10:15 AM CEST.
Compare 2 ways to travel from Palermo to Syracuse
Among the sustainable travel choices, the Bus stands out as a good way to reach Syracuse. The journey takes about 3 hours 20 minutes and with fares starting at just CLP 17 847, it presents an excellent value for a comfortable ride.
Where are the popular stops in Palermo and Syracuse?
Stops in Palermo
- AVia Tommaso Fazello, 16, 90123 Palermo PA, Italy
- BPunta Raisi, 90145, Palermo
- CPiazza Cairoli, 8-14, 90123 Palermo, Italy
- D90143 Palermo PA, Italy
- EVia Paolo Balsamo, 21, 90123 Palermo, Italy
- F
Via Paolo Balsamo, 31
Via Paolo Balsamo, 23-31, 90123 Palermo, Italy
Stops in Syracuse
- AViale Paolo Orsi, 20, 96100 Siracusa SR, Italy
- B
Siracusa
Piazzale della Stazione Centrale, 21, 96100 Siracusa SR, Italy - C
Siracusa - Terminal Bus (Stazione FS)
Viale Teocrito, 68-74, 96100 Siracusa SR, Italy
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Frequently asked questions about travelling from Palermo to Syracuse by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Palermo to Syracuse?
The cheapest bus tickets from Palermo to Syracuse start at CLP 17 847. The average price for this route is around CLP 17 955. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Palermo to Syracuse?
The average bus journey time from Palermo to Syracuse is 3h 20m, covering a distance of 204 km. The fastest bus gets you there in 3h 15m and is operated by Interbus Italy.
Which bus companies service the Palermo to Syracuse route?
Several major bus companies operate on this route with 6 buses available per day, including services from Interbus Italy, FlixBus.
What is the earliest and latest departure time for the bus from Palermo to Syracuse?
The earliest bus departs from Palermo to Syracuse at 08:00. And the latest bus departs at 17:05.
What are the CO₂ emissions for the bus trip from Palermo to Syracuse?
A bus trip from Palermo to Syracuse produces an estimated 5.099225 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
What is the best bus company from Palermo to Syracuse?
According to Busbud customers, the highest-rated bus company on this route is Interbus Italy, with an average rating of 4.0 out of 5 stars based on 618 reviews.
Which bus company has the best Wi-Fi from Palermo to Syracuse?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company offers the most punctual service from Palermo to Syracuse?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Palermo to Syracuse?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Interbus Italy, with a cleanliness rating of 4.5 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Palermo to Syracuse was searched and found on 18 Apr 2026 with a price of CLP 16 481To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Palermo to Syracuse as early as possible.
You can expect to pay from CLP 16 481 to CLP 42 801 for a bus ticket from Palermo to Syracuse based on the last 2 days. You can expect to find the cheapest price for the trip at CLP 16 481, which is on 2026-04-20.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Palermo to Syracuse?
The Bus is the cheapest travel choice for this destination
