Next departures for Palermo to Syracuse on November 19
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Terminal Bus Palermo
Syracuse bus station
Cheapest
Bus
Palermo Oreto Orsi
Syracuse bus station
Fastest
Bus
Terminal Bus Palermo
Syracuse bus station
No tags
Bus
Terminal Bus Palermo
Terminal Interbus
No tags
Bus
Terminal Bus Palermo
Syracuse bus station
No tags
Next departures for Palermo to Syracuse on November 20
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Terminal Bus Palermo
Syracuse bus station
Cheapest
Bus
Palermo Oreto Orsi
Syracuse bus station
Fastest
Bus
Terminal Bus Palermo
Syracuse bus station
No tags
Bus
Terminal Bus Palermo
Terminal Interbus
No tags
Bus
Terminal Bus Palermo
Syracuse bus station
No tags
Next departures for Palermo to Syracuse on November 21
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Terminal Bus Palermo
Syracuse bus station
Cheapest
Bus
Palermo Oreto Orsi
Syracuse bus station
Fastest
Bus
Terminal Bus Palermo
Syracuse bus station
No tags
Bus
Terminal Bus Palermo
Terminal Interbus
No tags
Bus
Terminal Bus Palermo
Syracuse bus station
No tags
Next departures for Palermo to Syracuse on November 22
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Terminal Bus Palermo
Syracuse bus station
Cheapest
Bus
Palermo Oreto Orsi
Syracuse bus station
Fastest
Bus
Terminal Bus Palermo
Syracuse bus station
No tags
Bus
Terminal Bus Palermo
Terminal Interbus
No tags
Bus
Terminal Bus Palermo
Syracuse bus station
No tags
Next departures for Palermo to Syracuse on November 23
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Terminal Bus Palermo
Syracuse bus station
Cheapest
Bus
Palermo Oreto Orsi
Syracuse bus station
Fastest
Bus
Terminal Bus Palermo
Syracuse bus station
No tags
Bus
Terminal Bus Palermo
Terminal Interbus
No tags
Bus
Terminal Bus Palermo
Syracuse bus station
No tags
Next departures for Palermo to Syracuse on November 24
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Terminal Bus Palermo
Syracuse bus station
Cheapest
Bus
Palermo Oreto Orsi
Syracuse bus station
Fastest
Bus
Terminal Bus Palermo
Syracuse bus station
No tags
Bus
Terminal Bus Palermo
Terminal Interbus
No tags
Bus
Terminal Bus Palermo
Syracuse bus station
No tags
Next departures for Palermo to Syracuse on November 25
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Terminal Bus Palermo
Syracuse bus station
Cheapest
Bus
Palermo Oreto Orsi
Syracuse bus station
Fastest
Bus
Terminal Bus Palermo
Syracuse bus station
No tags
Bus
Terminal Bus Palermo
Terminal Interbus
No tags
Bus
Terminal Bus Palermo
Syracuse bus station
No tags
Last refresh of the prices: Yesterday at 3:54 PM CET.
Compare 3 ways to go from Palermo to Syracuse
We recommend carpooling
Among the sustainable travel choices, the carpool stands out as the good way to reach Syracuse. The journey takes about 3 hours 10 minutes and with fares starting at just $14, it presents an excellent value for a comfortable ride.
The bus service receives high praise for its punctuality, cleanliness, and comfortable seating. Passengers appreciate the friendly and helpful drivers who ensure a smooth journey. The onboard amenities like Wi-Fi are valued by travelers. However, some passengers noted issues with ticketing options from certain locations and occasional disturbances from fellow travelers using mobile phones loudly during trips.
Interbus Palermo Syracuse recent customer reviews
driver was approachable and friendly. On time and felt safe. Made sure that all passengers are in before going especially when we had our toilet stop over.
5 out of 5 stars
Ellen A.
The trip was great and the driver was excellent. Only thing I dislike was a couple that has used their mobiles the whole trip in a extremly loud way for everything.
5 out of 5 stars
Susanne N.
The bus was on time and seats were fine
It advertised free WiFi but there was no automatic connection Reading the bar code just put me into the app no connection with WiFi. WHY NO SIGN just simply giving the password
I asked the driver who was disinterested and claimed he had no idea about WiFi
I tried to charge my phone with the outlet no power so my phone was flat by the time I arrived
Not a great experience
A pity Flix only operate occasionally
Maybe Interbus management should try travelling by Flix to learn how a bus company should operate. Learn from people who know !
Hopefully I can book for a more professional organisation for my return trip to Palermo
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Piazzale della Stazione Centrale, 21, 96100 Siracusa SR, Italy
C - Siracusa - Terminal Bus (Stazione FS)
Viale Teocrito, 68-74, 96100 Siracusa SR, Italy
Frequently asked questions about traveling from Palermo to Syracuse by bus
How far is Palermo from Syracuse?
Palermo and Syracuse are 128 miles (206 km) apart.
What are the departure and arrival stations when taking the bus from Palermo to Syracuse?
Most of the buses traveling from Palermo to Syracuse leave from Terminal Bus Palermo and arrive at Fermata dell'autobus Siracusa. These are the most popular pick-up and drop-off locations on this route, but you could find others that could be a better fit for your travel plans.
What are the best sights and things to do in Syracuse?
Once in Syracuse, you can start exploring the city and discover its surroundings. The top sights and things to do are Erie Canal Museum, Everson Museum of Art, Onondaga Lake Park, MOST and WonderWorks.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/17
$19
11/18
$19
Today
$19
11/20
$19
11/21
$19
11/22
$19
11/23
$19
11/24
$19
The cheapest trip from Palermo to Syracuse was searched and found on Nov 19, 2025 with a price of $19
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Palermo to Syracuse, as early as possible.
You can expect to pay from $19 to $33 for a bus ticket from Palermo to Syracuse based on the last 2 days. You can expect to find the cheapest price for the trip at $19 which is on 2025-11-22.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Palermo to Syracuse?
The bus is the cheapest travel choice for this destination
The cheapest trip from Palermo to Syracuse was searched and found on Nov 19, 2025 with a price of $19
The bus is the cheapest travel choice for this destination
