Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Terminal Bus Palermo | Syracuse bus station | Cheapest | ||||
| Bus | Palermo Oreto Orsi | Syracuse bus station | Fastest | ||||
| Bus | Terminal Bus Palermo | Syracuse bus station | No tags | ||||
 | Bus | Terminal Bus Palermo | Terminal Interbus | No tags | ||||
| Bus | Terminal Bus Palermo | Syracuse bus station | No tags | ||||
| Bus | Terminal Bus Palermo | Syracuse bus station | No tags | ||||
| Bus | Palermo Oreto Orsi | Syracuse bus station | No tags | ||||
| Bus | Palermo Oreto Orsi | Syracuse bus station | No tags |
Last refresh of the prices: Yesterday at 5:30 PM CEST.
Compare 2 ways to go from Palermo to Syracuse
Among the sustainable travel choices, the Bus stands out as a good way to reach Syracuse. The journey takes about 3 hours 20 minutes, and with fares starting at just CZK 396, it presents an excellent value for a comfortable ride.
Bus stations and stops in Palermo and Syracuse
Stops in Palermo
- A
Terminal Bus Palermo
Via Tommaso Fazello, 16, 90123 Palermo PA, Italy - B
Palermo Airport
Punta Raisi, 90145, Palermo - C
Piazza Cairoli
Piazza Cairoli, 8-14, 90123 Palermo, Italy - D
Fiera
90143 Palermo PA, Italy - E
Via Paolo Balsamo, 31
Via Paolo Balsamo, 23-31, 90123 Palermo, Italy - F
Piazza Ruggero Settimo, 12
Piazza Ruggero Settimo, 12C, 90139 Palermo, Italy
Stops in Syracuse
- A
Fermata dell'autobus Siracusa
Viale Paolo Orsi, 20, 96100 Siracusa SR, Italy - B
Siracusa
Piazzale della Stazione Centrale, 21, 96100 Siracusa SR, Italy - C
Siracusa - Terminal Bus (Stazione FS)
Viale Teocrito, 68-74, 96100 Siracusa SR, Italy
Compare bus companies
Frequently asked questions about travelling from Palermo to Syracuse by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Palermo to Syracuse?
The cheapest bus tickets from Palermo to Syracuse start from CZK 396. The average price for this route is around CZK 438. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Palermo to Syracuse?
The average bus travel time from Palermo to Syracuse is 3h 20m, covering a distance of 204 km. The quickest bus can get you there in 3h 15m and is operated by Interbus Italy.
Which bus companies service the Palermo to Syracuse route?
Several major bus companies operate on this route with 7 buses available per day, including services from Interbus Italy, FlixBus.
What are the earliest and latest departure times for the bus from Palermo to Syracuse?
The earliest bus departs from Palermo to Syracuse at 8:00am. And the latest bus departs at 5:05pm.
What are the CO₂ emissions for the bus trip from Palermo to Syracuse?
A bus trip from Palermo to Syracuse generates an estimated 5.09875 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Palermo to Syracuse?
According to Busbud customers, the highest-rated bus company on this route is Interbus Italy, with an average rating of 4.0 out of 5 stars based on 795 reviews.
Which bus company has the best Wi-Fi from Palermo to Syracuse?
Based on Busbud reviews, the bus company Interbus Italy has the highest Wi-Fi rating with a score of 2.8.
Which bus company has the best on-time performance from Palermo to Syracuse?
According to Busbud traveller reviews, the most punctual bus company on this route is Interbus Italy, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Palermo to Syracuse?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Interbus Italy, with a cleanliness rating of 4.6 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Palermo to Syracuse was searched and found on Sep 10, 2026 with a price of CZK 317To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Palermo to Syracuse, as early as possible.
You can expect to pay from CZK 317 to CZK 407 for a bus ticket from Palermo to Syracuse based on the last 2 days. You can expect to find the cheapest price for the trip at CZK 317 which is on 2026-09-10.
Usually FlixBus, Interbus Italy will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Palermo to Syracuse?
The Bus is the cheapest travel choice for this destination
