Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Pittsburgh Intermodal Station | Knoxville Bus Station | Cheapest | ||||
| Bus | Pittsburgh Intermodal Station | Knoxville Bus Station | Fastest |
Last refresh of the prices: Today at 9:46 AM EST.
Get from Pittsburgh to Knoxville
The journey takes about 17 hours 20 minutes, and with fares starting at just R 2 206, it presents an excellent value for a comfortable ride.
Where are the popular stops in Pittsburgh and Knoxville?
Stops in Pittsburgh
- A55 11th St, Pittsburgh, PA 15222, USA
- B
Sennott Square
201 S Bouquet St, Pittsburgh, PA 15213, USA
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Compare bus companies
Based on 87499 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. Greyhound ticket prices on this trip start at R 2 206
Frequently asked questions about travelling from Pittsburgh to Knoxville, TN by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Pittsburgh to Knoxville?
The cheapest bus tickets from Pittsburgh to Knoxville start at R 2 206. The average price for this route is around R 2 711. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Pittsburgh to Knoxville?
The average bus journey time from Pittsburgh to Knoxville is 17h 20m, covering a distance of 600 km. The fastest bus gets you there in 17h 20m and is operated by Greyhound.
Which bus companies service the Pittsburgh to Knoxville route?
Several major bus companies operate on this route with 2 buses available per day.
What is the earliest and latest departure time for the bus from Pittsburgh to Knoxville?
The earliest bus departs from Pittsburgh to Knoxville at 01:35. And the latest bus departs at 21:00.
What are the CO₂ emissions for the bus trip from Pittsburgh to Knoxville?
A bus trip from Pittsburgh to Knoxville produces an estimated 15 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Pittsburgh to Knoxville, TN was searched and found on 14 Jan 2026 with a price of R 2 052To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Pittsburgh to Knoxville, TN as early as possible.
You can expect to pay from R 2 052 to R 2 271 for a bus ticket from Pittsburgh to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at R 2 052, which is on 2026-01-14.
