Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Pittsburgh Intermodal Station | Knoxville Bus Station | CheapestFastest |
Last refresh of the prices: Yesterday at 9:49 PM EST.
Get from Pittsburgh to Knoxville
The journey takes about 17 hours 20 minutes, and with fares starting at just $119, it presents an excellent value for a comfortable ride.
Where are the popular stops in Pittsburgh and Knoxville?
Stops in Pittsburgh
- A55 11th St, Pittsburgh, PA 15222, USA
- B
Sennott Square
201 S Bouquet St, Pittsburgh, PA 15213, USA
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Compare bus companies
Based on 87496 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $119
Frequently asked questions about travelling from Pittsburgh to Knoxville, TN by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Pittsburgh to Knoxville?
The cheapest bus tickets from Pittsburgh to Knoxville start from $119. The average price for this route is around $221. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Pittsburgh to Knoxville?
The average bus travel time from Pittsburgh to Knoxville is 17h 20m, covering a distance of 600 km. The quickest bus can get you there in 17h 20m and is operated by Greyhound.
Which bus companies service the Pittsburgh to Knoxville route?
Several major bus companies operate on this route with 2 buses available per day.
What are the earliest and latest departure times for the bus from Pittsburgh to Knoxville?
The earliest bus departs from Pittsburgh to Knoxville at 1:35am. And the latest bus departs at 9:00pm.
What are the CO₂ emissions for the bus trip from Pittsburgh to Knoxville?
A bus trip from Pittsburgh to Knoxville generates an estimated 15 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Pittsburgh to Knoxville, TN was searched and found on Jan 12, 2026 with a price of $190To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Pittsburgh to Knoxville, TN, as early as possible.
