Bus Tickets from Pittsburgh to Knoxville (TN)

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TodayJun 13
TomorrowJun 14
SunJun 15
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WedJun 18
from US$118
ThuJun 19
from US$101
FriJun 20

Cheap buses leaving Wednesday

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: June 18 at
    Departure city: Pittsburgh
    Departure location: Pittsburgh Intermodal Station
    Arrival time: June 19 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: June 18 at
    Departure city: Pittsburgh
    Departure location: Pittsburgh Intermodal Station
    Arrival time: June 18 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 18 at
    Departure city: Pittsburgh
    Departure location: Pittsburgh Intermodal Station
    Arrival time: June 18 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

Last refresh of the prices: Last Wednesday at 6:12 PM EDT.

Prices and availability are subject to change.

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Bus Pittsburgh to Knoxville: Trip Overview

Average Ticket PriceUS$103
Average Bus Trip Duration21h 30m
Number of daily buses1
Earliest bus departure1:35am
Distance600 km
Latest bus departure8:35pm

Pittsburgh to Knoxville Bus

With Busbud, comparing and booking tickets for a bus from Pittsburgh to Knoxville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from Pittsburgh to Knoxville will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses travelling from Pittsburgh to Knoxville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Pittsburgh - Knoxville (TN)

  1. How long does it take to get to Knoxville from Pittsburgh by bus?

    The typical travel time from Pittsburgh to Knoxville by bus is around 21h 30m. The fastest bus on this trip will get to Knoxville in 17h 35m

  2. What is the distance between Pittsburgh and Knoxville?

    The distance covered from Pittsburgh to Knoxville is 606 km (376 miles).

  3. What are the departure and arrival locations for buses traveling from Pittsburgh to Knoxville?

    Buses traveling this route start their trip at Intermodal Station, in Pittsburgh, and end it at 100 Kirkwood St, in Knoxville.

  4. What is the cheapest way to go from Pittsburgh to Knoxville?

    Taking the bus is the cheapest option to travel from Pittsburgh to Knoxville. Starting at US$98, this bus is the most cost-effective option for your journey.

  5. How much is the bus from Pittsburgh to Knoxville?

    The bus fare from Pittsburgh to Knoxville is approximately US$103.

  6. Is it possible to travel by overnight bus from Pittsburgh to Knoxville?

    Yes! Catch buses leaving from Pittsburgh until 8:35pm and reaching Knoxville on the following day.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
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06-18
US$110
busbud logoThe cheapest trip from Pittsburgh to Knoxville was searched and found on Jun 18, 2025 with a price of US$110

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Pittsburgh to Knoxville, as early as possible.

You can expect to pay from US$110 to US$157 for a bus ticket from Pittsburgh to Knoxville based on the last 2 days. You can expect to find the cheapest price for the trip at US$110 which is on 2025-06-18.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Pittsburgh to Knoxville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from Pittsburgh to Knoxville, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Pittsburgh to Knoxville that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Pittsburgh to Knoxville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Will you be returning to Pittsburgh by bus?

Bus from Pittsburgh to Knoxville

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