Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Pittsburgh Intermodal Station | Knoxville Bus Station | No tags | ||||
| Bus | Pittsburgh Intermodal Station | Knoxville Bus Station | No tags | ||||
| Bus | Pittsburgh Intermodal Station | Knoxville Bus Station | No tags | ||||
| Bus | Pittsburgh Intermodal Station | Knoxville Bus Station | No tags | ||||
| Bus | Pittsburgh Intermodal Station | Knoxville Bus Station | No tags |
Get from Pittsburgh to Knoxville
The journey takes about 17 hours 40 minutes and with fares starting at just $82, it presents an excellent value for a comfortable ride.
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Where are the popular stops in Pittsburgh and Knoxville?
Frequently asked questions about traveling from Pittsburgh to Knoxville, TN by bus
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Pittsburgh to Knoxville, TN was searched and found on Nov 10, 2025 with a price of $80To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Pittsburgh to Knoxville, TN, as early as possible.
Top traveled bus routes
People from around the world trust Busbud
Popular Buses Connecting Pittsburgh
Buses Leaving from Pittsburgh
- Bus from Pittsburgh to Cincinnati
- Bus Pittsburgh - Philadelphia
- Pittsburgh - Boston
- Bus from Pittsburgh to Las Vegas
- Bus Pittsburgh - Denver
- Pittsburgh - Atlanta
- Bus from Pittsburgh to New York City
- Bus Pittsburgh - Washington
- Pittsburgh - State College
- Bus from Pittsburgh to Columbus
- Bus Pittsburgh - Baltimore
- Pittsburgh - Cleveland
- Bus from Pittsburgh to Newark
- Bus Pittsburgh - Chicago
- Pittsburgh - Orlando
Buses Going to Pittsburgh
- Bus from Greensburg to Pittsburgh
- Bus Temple - Pittsburgh
- Bakersfield - Pittsburgh
- Bus from Boston to Pittsburgh
- Bus Allentown - Pittsburgh
- Philadelphia - Pittsburgh
- Bus from New York City to Pittsburgh
- Bus Washington - Pittsburgh
- Baltimore - Pittsburgh
- Bus from State College to Pittsburgh
- Bus Columbus - Pittsburgh
- Cleveland - Pittsburgh
- Bus from Newark to Pittsburgh
- Bus Harrisburg - Pittsburgh
- Erie - Pittsburgh
Popular Buses Connecting Knoxville
Buses Leaving from Knoxville
- Bus from Knoxville to Charlotte
- Bus Knoxville - Marathon
- Knoxville - Lexington
- Bus from Knoxville to Orlando
- Bus Knoxville - Chicago
- Knoxville - Miami
- Bus from Knoxville to Nashville
- Bus Knoxville - Atlanta
- Knoxville - New York City
- Bus from Knoxville to Memphis
- Bus Knoxville - Washington
- Knoxville - Tampa
- Bus from Knoxville to Jackson
- Bus Knoxville - Cleveland
- Knoxville - Cincinnati
Buses Going to Knoxville
- Bus from Nashville to Knoxville
- Bus Memphis - Knoxville
- Charlotte - Knoxville
- Bus from Chicago to Knoxville
- Bus Tampa - Knoxville
- Detroit - Knoxville
- Bus from Atlanta to Knoxville
- Bus Hartford - Knoxville
- New York City - Knoxville
- Bus from Louisville to Knoxville
- Bus Cincinnati - Knoxville
- Lexington - Knoxville
- Bus from Dallas to Knoxville
- Bus Orlando - Knoxville
- Greenville - Knoxville
Popular routes in this country
- Bus from Fort Lauderdale to Orlando
- Bus Dallas - Houston
- Albany - New York City
- Bus from Las Vegas to Los Angeles
- Bus Tampa - Miami
- Austin - Dallas
- Bus from Dallas to Austin
- Bus Miami - Tampa
- Austin - Houston
- Bus from Houston to San Antonio
- Bus Seattle - Leavenworth
- Houston - Austin
- Bus from San Antonio to Houston
- Bus Atlanta - Orlando
- Providence - New York City