Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Prague (Main Station - parking) | Mainz | Cheapest | ||||
| Bus | Prague (Na Knížecí) | Mainz | Fastest | ||||
| Bus | Prague (Central Bus Station Florenc) | Mainz | No tags | ||||
| Bus | Prague (Central Bus Station Florenc) | Mainz | No tags | ||||
| Bus | Prague (Na Knížecí) | Mainz | No tags | ||||
| Bus | PRG Airport | Mainz | No tags | ||||
| Bus | PRG Airport | Mainz | No tags |
Last refresh of the prices: Today at 9:03 AM CEST.
Compare 2 ways to travel from Prague to Mainz
Among the sustainable travel choices, the Bus stands out as a good way to reach Mainz. The journey takes about 11 hours 35 minutes and with fares starting at just CHF 37, it presents an excellent value for a comfortable ride.
Bus stations and stops in Prague and Mainz
Stops in Prague
- A
PRG Airport
Aviatická, 161 08, Praha 6, Czechia - B
Černý Most
Chlumecká, 198 00 Praha 20, Czech Republic - C
Florenc
Křižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic - D
Tomíčkova
Tomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia - E
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic - F
Hlavní nádraží
300/8 Wilsonova, 110 00 Praha, Czechia
Stops in Mainz
- A
Mainz
Hechtsheimer Str. 65, 55131 Mainz, Germany - B
Mainz- Kaiser-Wilhelm-Ring 16- gegenüberliegende Straßenseite
Kaiser-Wilhelm-Ring 16 (gegenüberliegende Straßenseite), 55118 Mainz
Compare bus companies
Based on 15378 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained about the Wi-Fi. FlixBus ticket prices on this trip start at CHF 37
Frequently asked questions about travelling from Prague to Mainz by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Prague to Mainz?
The cheapest bus tickets from Prague to Mainz start at CHF 37. The average price for this route is around CHF 52. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Prague to Mainz?
The average bus journey time from Prague to Mainz is 11h 35m, covering a distance of 437 km. The fastest bus gets you there in 8h 20m and is operated by FlixBus.
Which bus companies service the Prague to Mainz route?
Several major bus companies operate on this route with 6 buses available per day.
What is the earliest and latest departure time for the bus from Prague to Mainz?
The earliest bus departs from Prague to Mainz at 03:25. And the latest bus departs at 23:05.
What are the CO₂ emissions for the bus trip from Prague to Mainz?
A bus trip from Prague to Mainz produces an estimated 10.922225000000001 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Prague to Mainz was searched and found on 01 Sept 2026 with a price of CHF 29To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Prague to Mainz as early as possible.
You can expect to pay from CHF 29 to CHF 94 for a bus ticket from Prague to Mainz based on the last 2 days. You can expect to find the cheapest price for the trip at CHF 29, which is on 2026-09-01.
