Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Prague (Main Station - parking) | Mainz | Cheapest | ||||
| Bus | Prague (Na Knížecí) | Mainz | Fastest | ||||
| Bus | Prague (Central Bus Station Florenc) | Mainz | No tags | ||||
| Bus | Prague (Na Knížecí) | Mainz | No tags | ||||
| Bus | PRG Airport | Mainz | No tags | ||||
| Bus | PRG Airport | Mainz | No tags |
Last refresh of the prices: Today at 12:14 AM CEST.
Compare 2 ways to go from Prague to Mainz
Among the sustainable travel choices, the Bus stands out as a good way to reach Mainz. The journey takes about 11 hours 35 minutes, and with fares starting at just PEN 131, it presents an excellent value for a comfortable ride.
Bus stations and stops in Prague and Mainz
Stops in Prague
- A
PRG Airport
Aviatická, 161 08, Praha 6, Czechia - B
Florenc
Křižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic - C
Černý Most
Chlumecká, 198 00 Praha 20, Czech Republic - D
Tomíčkova
Tomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia - E
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic - F
Hlavní nádraží
300/8 Wilsonova, 110 00 Praha, Czechia
Stops in Mainz
- A
Mainz
Hechtsheimer Str. 65, 55131 Mainz, Germany - B
Mainz- Kaiser-Wilhelm-Ring 16- gegenüberliegende Straßenseite
Kaiser-Wilhelm-Ring 16 (gegenüberliegende Straßenseite), 55118 Mainz
Compare bus companies
Based on 13027 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi‑Fi. FlixBus ticket prices on this trip start at PEN 131
Frequently asked questions about travelling from Prague to Mainz by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Prague to Mainz?
The cheapest bus tickets from Prague to Mainz start from PEN 131. The average price for this route is around PEN 185. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Prague to Mainz?
The average bus travel time from Prague to Mainz is 11h 35m, covering a distance of 436 km. The quickest bus can get you there in 8h 5m and is operated by FlixBus.
Which bus companies service the Prague to Mainz route?
Several major bus companies operate on this route with 5 buses available per day.
What are the earliest and latest departure times for the bus from Prague to Mainz?
The earliest bus departs from Prague to Mainz at 3:25am. And the latest bus departs at 11:05pm.
What are the CO₂ emissions for the bus trip from Prague to Mainz?
A bus trip from Prague to Mainz generates an estimated 10.899899999999999 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Prague to Mainz was searched and found on Jul 15, 2026 with a price of PEN 146To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Prague to Mainz, as early as possible.
You can expect to pay from PEN 146 to PEN 601 for a bus ticket from Prague to Mainz based on the last 2 days. You can expect to find the cheapest price for the trip at PEN 155 which is on 2026-07-18.
