Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | PRG Airport | Mainz | Cheapest | ||||
| Bus | Prague (Na Knížecí) | Mainz | Fastest | ||||
| Bus | Prague (Main Station - parking) | Mainz | No tags | ||||
| Bus | Prague (Na Knížecí) | Mainz | No tags | ||||
| Bus | PRG Airport | Mainz | No tags |
Last refresh of the prices: Today at 7:26 AM CEST.
Compare 2 ways to go from Prague to Mainz
Among the sustainable travel choices, the Bus stands out as a good way to reach Mainz. The journey takes about 11 hours 35 minutes, and with fares starting at just $57, it presents an excellent value for a comfortable ride.
Where are the popular stops in Prague and Mainz?
Stops in Prague
- AAviatická, 161 08, Praha 6, Czechia
- BKřižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic
- CChlumecká, 198 00 Praha 20, Czech Republic
- DTomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia
- E
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic - F300/8 Wilsonova, 110 00 Praha, Czechia
Stops in Mainz
- A
Mainz
Hechtsheimer Str. 65, 55131 Mainz, Germany - B
Mainz- Kaiser-Wilhelm-Ring 16- gegenüberliegende Straßenseite
Kaiser-Wilhelm-Ring 16 (gegenüberliegende Straßenseite), 55118 Mainz - C
Bahnhofstraße
flibco.com bus stop, Kaiser-Wilhelm-Ring, 55118 Mainz, Germany
Compare bus companies
Based on 12479 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the Wi‑Fi. FlixBus ticket prices on this trip start at $57
Frequently asked questions about travelling from Prague to Mainz by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Prague to Mainz?
The cheapest bus tickets from Prague to Mainz start from $57. The average price for this route is around $82. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Prague to Mainz?
The average bus travel time from Prague to Mainz is 11h 35m, covering a distance of 439 km. The quickest bus can get you there in 8h 5m and is operated by FlixBus.
Which bus companies service the Prague to Mainz route?
Several major bus companies operate on this route with 4 buses available per day.
What are the earliest and latest departure times for the bus from Prague to Mainz?
The earliest bus departs from Prague to Mainz at 3:50am. And the latest bus departs at 10:45pm.
What are the CO₂ emissions for the bus trip from Prague to Mainz?
A bus trip from Prague to Mainz generates an estimated 10.973 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Prague to Mainz was searched and found on Apr 14, 2026 with a price of $53To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Prague to Mainz, as early as possible.
You can expect to pay from $53 to $155 for a bus ticket from Prague to Mainz based on the last 2 days. You can expect to find the cheapest price for the trip at $59 which is on 2026-04-16.
