Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Prague (Main Station - parking) | Mainz | Cheapest | ||||
| Bus | Prague (Na Knížecí) | Mainz | Fastest | ||||
| Bus | Prague (Central Bus Station Florenc) | Mainz | No tags | ||||
| Bus | Prague (Na Knížecí) | Mainz | No tags | ||||
| Bus | PRG Airport | Mainz | No tags | ||||
| Bus | PRG Airport | Mainz | No tags |
Last refresh of the prices: Today at 11:30 AM CEST.
Compare 2 ways to go from Prague to Mainz
Among the sustainable travel choices, the Bus stands out as a good way to reach Mainz. The journey takes about 11 hours 35 minutes and with fares starting at just MAD 358, it presents an excellent value for a comfortable ride.
Bus stations and stops in Prague and Mainz
Stops in Prague
- A
PRG Airport
Aviatická, 161 08, Praha 6, Czechia - B
Florenc
Křižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic - C
Černý Most
Chlumecká, 198 00 Praha 20, Czech Republic - D
Tomíčkova
Tomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia - E
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic - F
Hlavní nádraží
300/8 Wilsonova, 110 00 Praha, Czechia
Stops in Mainz
- A
Mainz
Hechtsheimer Str. 65, 55131 Mainz, Germany - B
Mainz- Kaiser-Wilhelm-Ring 16- gegenüberliegende Straßenseite
Kaiser-Wilhelm-Ring 16 (gegenüberliegende Straßenseite), 55118 Mainz
Compare bus companies
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Prague to Mainz by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Prague to Mainz?
The cheapest bus tickets from Prague to Mainz start from MAD 358. The average price for this route is around MAD 507. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Prague to Mainz?
The average bus trip duration from Prague to Mainz is 11h 35m, covering a distance of 271 miles (436 km). The quickest bus can get you there in 8h 5m and is operated by FlixBus.
Which bus companies service the Prague to Mainz route?
Several major bus companies operate on this route with 5 buses available per day.
What is the earliest and latest departure time for the bus from Prague to Mainz?
The earliest bus departs from Prague to Mainz at 3:25am. And the latest bus departs at 11:05pm.
What are the CO₂ emissions for the bus trip from Prague to Mainz?
A bus trip from Prague to Mainz generates an estimated 10.899899999999999 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Prague to Mainz was searched and found on Jul 15, 2026 with a price of MAD 401To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Prague to Mainz, as early as possible.
You can expect to pay from MAD 401 to MAD 1,648 for a bus ticket from Prague to Mainz based on the last 2 days. You can expect to find the cheapest price for the trip at MAD 494 which is on 2026-07-17.
