Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | UCSD Health La Jolla Station | Chicago 95Th & Dan Ryan | Cheapest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | UCSD Health La Jolla Station | Downtown Greyhound Station | Fastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | San Diego (Old Town-FlixBus) | Downtown Greyhound Station | No tags | ||||
 | Bus | Greyhound Bus Stop | Downtown Greyhound Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | San Diego (Old Town-FlixBus) | 537-517 W. Jackson Blvd | No tags |
Last refresh of the prices: Yesterday at 11:09 AM PST.
Compare 2 ways to travel from San Diego to Chicago
Among the sustainable travel choices, the train stands out as a good way to reach Chicago. The journey takes about 1 day, 22 hours 41 minutes and with fares starting at just R 3 193, it presents an excellent value for a comfortable ride.
Where are the popular stops in San Diego and Chicago?
Stops in San Diego
- A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA - B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA - C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA - D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA - E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA - F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- B
Chicago O'Hare International Airport
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Compare bus companies
Frequently asked questions about travelling from San Diego, CA, US to Chicago by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from San Diego to Chicago?
The cheapest bus tickets from San Diego to Chicago start at R 2 309. The average price for this route is around R 4 737. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from San Diego to Chicago?
The average bus journey time from San Diego to Chicago is 2d 6h, covering a distance of 2787 km. The fastest bus gets you there in 2d 4h and is operated by FlixBus.
Which bus companies service the San Diego to Chicago route?
What is the earliest and latest departure time for the bus from San Diego to Chicago?
The earliest bus departs from San Diego to Chicago at 06:45. And the latest bus departs at 19:35.
What are the CO₂ emissions for the bus trip from San Diego to Chicago?
A bus trip from San Diego to Chicago produces an estimated 70 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
What is the best bus company from San Diego to Chicago?
According to Busbud customers, the highest-rated bus company on this route is Amtrak, with an average rating of 4.1 out of 5 stars based on 5627 reviews.
Which bus company has the best Wi-Fi from San Diego to Chicago?
Based on reviews on Busbud, the bus company Amtrak has the best Wi-Fi rating with a score of 3.6.
Which bus company offers the most punctual service from San Diego to Chicago?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from San Diego to Chicago?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Amtrak, with a cleanliness rating of 4.5 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Diego, CA, US to Chicago was searched and found on 20 Dec 2025 with a price of R 3 400To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to Chicago as early as possible.
You can expect to pay from R 3 400 to R 8 607 for a bus ticket from San Diego, CA, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at R 3 400, which is on 2025-12-20.
What's the cheapest way to go from San Diego, CA, US to Chicago?
The bus is the cheapest travel choice for this destination
