How much is the bus ticket from San Diego to Chicago?

The cheapest coach tickets from San Diego to Chicago start from £100. The average price for this route is around £226. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus journey from San Diego to Chicago?

The average bus journey time from San Diego to Chicago is 2d 6h, covering a distance of 1725 miles. The fastest bus can take you there in 1d 23h and is operated by Amtrak .

Which bus companies service the San Diego to Chicago route?

Several major bus companies operate on this route with 26 buses available per day, including services from Greyhound , Amtrak , FlixBus .

What is the earliest and latest departure time for the bus from San Diego to Chicago?

The earliest bus departs from San Diego to Chicago at 06:45. And the latest bus departs at 19:35.

What are the CO₂ emissions for the bus trip from San Diego to Chicago?

A bus journey from San Diego to Chicago produces an estimated 70 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.

Which is the best bus company from San Diego to Chicago?

According to Busbud customers, the highest-rated bus company on this route is Amtrak , with an average rating of 4.1 out of 5 stars based on 5696 reviews.

Which company has the best Wi-Fi from San Diego to Chicago?

Based on Busbud reviews, the bus company Amtrak has the best Wi-Fi rating with a score of 3.6.

Which bus company offers the most punctual service from San Diego to Chicago?

According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus , with a punctuality rating of 3.9 out of 5 stars.

Which bus company has the cleanest buses from San Diego to Chicago?

According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Amtrak , with a cleanliness rating of 4.5 out of 5 stars.

Bus San Diego to Chicago from £104 | Refundable Tickets

Next departures

Next departures from San Diego to Chicago on 10 January
Operated by	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	15:55	San Diego (Old Town-FlixBus)	2d 14h	08:00	537-517 W. Jackson Blvd	Cheapest
	19:35	Greyhound Bus Stop	2d 6h	04:10	Downtown Greyhound Station	Fastest
	15:00	Santa Fe Depot	2d 21h	14:39	Chicago (Union Station), IL	No tags
FlixBus + Greyhound Lines, Inc.	15:55	San Diego (Old Town-FlixBus)	2d 10h	04:10	Downtown Greyhound Station	No tags
	19:35	Greyhound Bus Stop	2d 10h	08:00	537-517 W. Jackson Blvd	No tags

Next departures from San Diego to Chicago on 11 January
Operated by	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	12:45	Santa Fe Depot	1d 23h	14:42	Chicago (Union Station), IL	CheapestFastest
	12:45	Santa Fe Depot	1d 23h	14:42	Chicago (Union Station), IL	No tags
FlixBus + Greyhound Lines, Inc.	12:15	San Diego (Old Town-FlixBus)	2d 2h	16:30	Downtown Greyhound Station	No tags
	19:35	Greyhound Bus Stop	2d 6h	04:10	Downtown Greyhound Station	No tags
	12:45	Santa Fe Depot	1d 23h	14:42	Chicago (Union Station), IL	No tags

Next departures from San Diego to Chicago on 12 January
Operated by	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	12:15	San Diego (Old Town-FlixBus)	2d 2h	16:30	Downtown Greyhound Station	Cheapest
FlixBus + Greyhound Lines, Inc.	13:35	UCSD Health La Jolla Station	2d	16:30	Downtown Greyhound Station	Fastest
FlixBus + Greyhound Lines, Inc.	15:55	San Diego (Old Town-FlixBus)	2d 10h	04:10	Downtown Greyhound Station	No tags
	19:35	Greyhound Bus Stop	2d 6h	04:10	Downtown Greyhound Station	No tags
FlixBus + Greyhound Lines, Inc.	15:55	San Diego (Old Town-FlixBus)	2d 14h	08:00	537-517 W. Jackson Blvd	No tags

Next departures from San Diego to Chicago on 13 January
Operated by	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	09:25	San Diego (Old Town-FlixBus)	2d 5h	16:30	Downtown Greyhound Station	Cheapest
FlixBus + Greyhound Lines, Inc.	13:35	UCSD Health La Jolla Station	2d	16:30	Downtown Greyhound Station	Fastest
FlixBus + Greyhound Lines, Inc.	09:25	San Diego (Old Town-FlixBus)	2d 20h	08:00	537-517 W. Jackson Blvd	No tags
	19:35	Greyhound Bus Stop	2d 6h	04:10	Downtown Greyhound Station	No tags
FlixBus + Greyhound Lines, Inc.	13:35	UCSD Health La Jolla Station	2d 16h	08:00	537-517 W. Jackson Blvd	No tags

Next departures from San Diego to Chicago on 14 January
Operated by	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	13:35	UCSD Health La Jolla Station	2d 16h	08:00	537-517 W. Jackson Blvd	Cheapest
FlixBus + Greyhound Lines, Inc.	13:35	UCSD Health La Jolla Station	2d	16:30	Downtown Greyhound Station	Fastest
FlixBus + Greyhound Lines, Inc.	09:25	San Diego (Old Town-FlixBus)	2d 5h	16:30	Downtown Greyhound Station	No tags
	19:35	Greyhound Bus Stop	2d 6h	04:10	Downtown Greyhound Station	No tags
FlixBus + Greyhound Lines, Inc.	09:25	San Diego (Old Town-FlixBus)	2d 20h	08:00	537-517 W. Jackson Blvd	No tags

Next departures from San Diego to Chicago on 15 January
Operated by	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	15:55	San Diego (Old Town-FlixBus)	2d 10h	04:10	Downtown Greyhound Station	Cheapest
FlixBus + Greyhound Lines, Inc.	13:35	UCSD Health La Jolla Station	2d	16:30	Downtown Greyhound Station	Fastest
FlixBus + Greyhound Lines, Inc.	09:25	San Diego (Old Town-FlixBus)	2d 5h	16:30	Downtown Greyhound Station	No tags
	19:35	Greyhound Bus Stop	2d 6h	04:10	Downtown Greyhound Station	No tags
FlixBus + Greyhound Lines, Inc.	15:55	San Diego (Old Town-FlixBus)	2d 14h	08:00	537-517 W. Jackson Blvd	No tags

Next departures from San Diego to Chicago on 16 January
Operated by	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	13:35	UCSD Health La Jolla Station	2d	16:30	Downtown Greyhound Station	CheapestFastest
FlixBus + Greyhound Lines, Inc.	12:15	San Diego (Old Town-FlixBus)	2d 2h	16:30	Downtown Greyhound Station	No tags
	19:35	Greyhound Bus Stop	2d 6h	04:10	Downtown Greyhound Station	No tags
FlixBus + Greyhound Lines, Inc.	15:55	San Diego (Old Town-FlixBus)	2d 10h	04:10	Downtown Greyhound Station	No tags
	19:35	Greyhound Bus Stop	2d 10h	08:00	537-517 W. Jackson Blvd	No tags

Next departures from San Diego to Chicago on 17 January
Operated by	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	10:00	Greyhound Bus Stop	2d 4h	16:30	Downtown Greyhound Station	Cheapest
FlixBus + Greyhound Lines, Inc.	13:35	UCSD Health La Jolla Station	2d	16:30	Downtown Greyhound Station	Fastest
FlixBus + Greyhound Lines, Inc.	12:15	San Diego (Old Town-FlixBus)	2d 2h	16:30	Downtown Greyhound Station	No tags
	19:35	Greyhound Bus Stop	2d 6h	04:10	Downtown Greyhound Station	No tags
FlixBus + Greyhound Lines, Inc.	15:55	San Diego (Old Town-FlixBus)	2d 10h	04:10	Downtown Greyhound Station	No tags

Last refresh of the prices: Last Monday at 14:19 PST.

Compare 2 ways to travel from San Diego to Chicago

We recommend taking the bus

Among the sustainable travel choices, the Bus stands out as a good way to reach Chicago. The journey takes about 2 days, 6 hours 20 minutes and with fares starting at just £100, it presents an excellent value for a comfortable ride.

26bus per day

2d 6hAverage duration

1725 milesDistance

70kgCO₂ emissions

	Average price	Average duration	CO₂ emissions	Actions
Bus	Average price£100 - £554	Average duration2d 6h	CO₂ emissions 70kg CO₂e
Train	Average price£142 - £1,340	Average duration1d 22h	CO₂ emissions 254kg CO₂e

Where are the popular stops in San Diego and Chicago?

Stops in San Diego

A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA
Map
B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA
Map
C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA
Map
D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA
Map
E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA
Map
F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA
Map

Stops in Chicago

A
Downtown Greyhound Station
630 W Harrison St, Chicago, IL 60607, USA
Visit page Map
B
Chicago O'Hare International Airport
Visit page Map
C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA
Map
D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA
Map
E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA
Map
F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Map

Compare bus companies

Greyhound

3.5/587,492 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

WiFi2.4

Amtrak

4/55,723 reviews

Staff4.7

Timeliness3.8

Cleanliness4.6

WiFi3.6

FlixBus

3.5/511,989 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

WiFi2.7

US bus companies:FlixBus, BlaBlaCar Bus, Greyhound, ALSA, Intercape, Trenitalia, Big Sky

Frequently asked questions about travelling by bus from San Diego, CA, US to Chicago

Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.

How much is the bus ticket from San Diego to Chicago?
The cheapest coach tickets from San Diego to Chicago start from £100. The average price for this route is around £226. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from San Diego to Chicago?
The average bus journey time from San Diego to Chicago is 2d 6h, covering a distance of 1725 miles. The fastest bus can take you there in 1d 23h and is operated by Amtrak.
Which bus companies service the San Diego to Chicago route?
Several major bus companies operate on this route with 26 buses available per day, including services from Greyhound, Amtrak, FlixBus.
What is the earliest and latest departure time for the bus from San Diego to Chicago?
The earliest bus departs from San Diego to Chicago at 06:45. And the latest bus departs at 19:35.
What are the CO₂ emissions for the bus trip from San Diego to Chicago?
A bus journey from San Diego to Chicago produces an estimated 70 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Which is the best bus company from San Diego to Chicago?
According to Busbud customers, the highest-rated bus company on this route is Amtrak, with an average rating of 4.1 out of 5 stars based on 5696 reviews.
Which company has the best Wi-Fi from San Diego to Chicago?
Based on Busbud reviews, the bus company Amtrak has the best Wi-Fi rating with a score of 3.6.
Which bus company offers the most punctual service from San Diego to Chicago?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from San Diego to Chicago?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Amtrak, with a cleanliness rating of 4.5 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

08/01

£322

09/01

£366

Today

£160

11/01

£186

12/01

£255

13/01

£159

14/01

£174

15/01

£215

The cheapest trip from San Diego, CA, US to Chicago was searched and found on 13 Jan 2026 with a price of £159

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to Chicago as early as possible.

You can expect to pay from £159 to £1,143 for a bus ticket from San Diego, CA, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at £159, which is on 2026-01-13.