Find coaches from San Luis Obispo to Santa Clara, US

Next departures

Next departures from San Luis Obispo to Santa Clara on 1 November
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Amtrak
    		Cal Poly Vista Grande Dining Complex
    		Santa Ana Regional Transportation CenterCheapest
    Amtrak
      		Cal Poly Vista Grande Dining Complex
      		Santa Clara Transit CenterFastest
      Amtrak
        		Cal Poly Vista Grande Dining Complex
        		Great America StationNo tags
        Amtrak
          		Cal Poly Vista Grande Dining Complex
          		Great America StationNo tags
          Amtrak
            		Cal Poly Vista Grande Dining Complex
            		Great America StationNo tags

            Last refresh of the prices: Yesterday at 3:17 AM PDT.

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            Compare 2 ways to travel from San Luis Obispo to Santa Clara

            We recommend taking the train

            Among the sustainable travel choices, the train stands out as a good way to reach Santa Clara. The journey takes about 6 hours 49 minutes and with fares starting at just US$49, it presents an excellent value for a comfortable ride.

            2train per day
            6h 49mAverage duration
            308 kmDistance
            28kgCO₂ emissions
            Bus
            		Average priceUS$76 - US$80Average duration8h 15m
            8kg CO₂e
            Train
            		Average priceUS$49 - US$110Average duration6h 49m
            28kg CO₂e

            Bus San Luis Obispo to Santa Clara, US: Trip Overview

            Average ticket priceUS$76
            Average bus trip duration8h 15m
            Number of daily buses1
            Earliest bus departure18:50
            Distance309 km
            Latest bus departure19:25

            San Luis Obispo to Santa Clara Bus

            Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from San Luis Obispo to Santa Clara.

            We make it our job to connect you with the most dependable bus companies that cover bus service from San Luis Obispo to Santa Clara.

            Discover how much the bus trip from San Luis Obispo to Santa Clara will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

            Frequently asked questions on the trip San Luis Obispo - Santa Clara, US

            1. How much does a bus ticket from San Luis Obispo to Santa Clara cost?

              The bus ticket price from San Luis Obispo to Santa Clara starts at US$76. The best way to find cheap bus tickets from San Luis Obispo to Santa Clara is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

            2. How long is the bus ride from San Luis Obispo to Santa Clara?

              The average travel time between San Luis Obispo and Santa Clara is around 8h 15m, although the fastest bus will take about 8h 5m. This is the time it takes to travel the 264 km that separates the two cities.

            3. How many daily bus connections are there between San Luis Obispo and Santa Clara?

              The number of buses from San Luis Obispo to Santa Clara can differ depending on the day of the week. On average, there are 1 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from San Luis Obispo to Santa Clara by comparing and selecting the bus that fits your travel style and budget on Busbud.

            4. Which bus companies travel from San Luis Obispo to Santa Clara?

              When taking the bus from San Luis Obispo to Santa Clara, you can travel comfortably and safely with Amtrak.

            Find cheapest prices for buses

            Price is for a one-way ticket for one passenger and based on past searches.

            Best price found
            29/10
            US$53
            30/10
            US$53
            Today
            US$53
            01/11
            US$53
            02/11
            US$53
            03/11
            US$53
            04/11
            US$53
            05/11
            US$64
            busbud logoThe cheapest trip from San Luis Obispo to Santa Clara, US was searched and found on 29 Oct 2025 with a price of US$53

            To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Luis Obispo to Santa Clara, US as early as possible.

            You can expect to pay from US$53 to US$101 for a bus ticket from San Luis Obispo to Santa Clara, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$53, which is on 2025-11-01.

            About Bus Travel

            Bus Travel Tips

            If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from San Luis Obispo to Santa Clara but it'll also be endearing to native speakers who will surely appreciate your effort.

            From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from San Luis Obispo to Santa Clara.

            Buses have the smallest carbon footprint of all motorized transport modes. A bus going from San Luis Obispo to Santa Clara will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

            Tune out to the fine sounds of your best music playlist on your bus trip from San Luis Obispo to Santa Clara while indulging in miles on end of beautiful scenic views.

            Did you know?

            The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

            The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

            Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

            Will you be returning to San Luis Obispo by bus?

            Bus from Santa Clara, US to San Luis Obispo

            You can also go to Santa Clara, US by train

            Train from San Luis Obispo to Santa Clara, US

            Why choose Busbud?

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            Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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