Find coaches from San Nicolás, CL to Santiago, CL

Next departures

Next departures from San Nicolás to Santiago on 9 November
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
EME Bus
    		Terminal de Autobuses de San Nicolas
    		Terminal SurCheapest
    EME Bus
      		Terminal de Autobuses de San Nicolas
      		Terminal SurFastest
      EME Bus
        		Terminal de Autobuses de San Nicolas
        		Terminal SurNo tags
        EME Bus
          		Terminal de Autobuses de San Nicolas
          		Terminal SurNo tags
          EME Bus
            		Terminal de Autobuses de San Nicolas
            		Terminal SurNo tags

            Last refresh of the prices: Last Sunday at 10:04 PM -03.

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            Get from San Nicolás to Santiago

            This route is served by bus only

            The journey takes about 4 hours 16 minutes, and with fares starting at just R 195, it presents an excellent value for a comfortable ride.

            3bus per day
            4h 16mAverage duration
            367 kmDistance
            9kgCO₂ emissions

            Bus San Nicolás, CL to Santiago, CL: Trip Overview

            Average ticket priceR 244
            Average bus trip duration4h 16m
            Number of daily buses3
            Earliest bus departure00:10
            Distance366 km
            Latest bus departure14:30

            San Nicolás to Santiago Bus

            Busbud helps you find a bus from San Nicolás to Santiago. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

            We make it our job to connect you with the most dependable bus companies that cover bus service from San Nicolás to Santiago.

            Discover how much the bus trip from San Nicolás to Santiago will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

            Frequently asked questions on the trip San Nicolás, CL - Santiago, CL

            1. How much does a bus ticket from San Nicolás to Santiago cost?

              The bus ticket price from San Nicolás to Santiago starts at R 195. The best way to find cheap bus tickets from San Nicolás to Santiago is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

            2. How long is the bus ride from San Nicolás to Santiago?

              The average travel time between San Nicolás and Santiago is around 4h 16m, although the fastest bus will take about 4h 16m. This is the time it takes to travel the 374 km that separates the two cities.

            3. How many daily bus connections are there between San Nicolás and Santiago?

              The number of buses from San Nicolás to Santiago can differ depending on the day of the week. On average, there are 3 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from San Nicolás to Santiago by comparing and selecting the bus that fits your travel style and budget on Busbud.

            4. Which bus companies travel from San Nicolás to Santiago?

              When taking the bus from San Nicolás to Santiago, you can travel comfortably and safely with Eme Bus.

            Find cheapest prices for buses

            Price is for a one-way ticket for one passenger and based on past searches.

            Best price found
            03/11
            No data
            04/11
            No data
            Today
            R 165
            06/11
            R 165
            07/11
            No data
            08/11
            No data
            09/11
            R 185
            10/11
            No data
            busbud logoThe cheapest trip from San Nicolás, CL to Santiago, CL was searched and found on 05 Nov 2025 with a price of R 165

            To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Nicolás, CL to Santiago, CL as early as possible.

            You can expect to pay from R 165 to R 287 for a bus ticket from San Nicolás, CL to Santiago, CL based on the last 2 days. You can expect to find the cheapest price for the trip at R 165, which is on 2025-11-06.

            About Bus Travel

            Bus Travel Tips

            Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between San Nicolás and Santiago!

            From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from San Nicolás to Santiago.

            Buses have the smallest carbon footprint of all motorized transport modes. A bus going from San Nicolás to Santiago will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

            Tune out to the fine sounds of your best music playlist on your bus trip from San Nicolás to Santiago while indulging in miles on end of beautiful scenic views.

            Did you know?

            Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

            One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

            It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

            Will you be returning to San Nicolás, CL by bus?

            Bus from Santiago, CL to San Nicolás, CL

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