Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Terminal de Autobuses de San Nicolas | Terminal Sur | Cheapest | ||||
| Bus | Terminal de Autobuses de San Nicolas | Terminal Sur | Fastest | ||||
| Bus | Terminal de Autobuses de San Nicolas | Terminal Sur | No tags | ||||
| Bus | Terminal de Autobuses de San Nicolas | Terminal Sur | No tags | ||||
| Bus | Terminal de Autobuses de San Nicolas | Terminal Sur | No tags |
Last refresh of the prices: Last Friday at 2:19 PM -03.
Get from San Nicolás to Santiago
The journey takes about 4 hours 16 minutes, and with fares starting at just $17, it presents an excellent value for a comfortable ride.
Where are the popular stops in San Nicolás and Santiago?
Stops in San Nicolás
- A
Terminal de Autobuses de San Nicolas
N-50 312-448, San Nicolás, Región del Bío Bío, Chile
Stops in Santiago
- ASantiago - Av Libertador Bernardo O'Higgins 3850, Santiago, Estación Central, Región Metropolitana, Chile
- B
San Borja
San Francisco de Borja 199-225, Santiago, Estación Central, Región Metropolitana, Chile - CTucapel Jiménez 21, 8340528 Santiago, Región Metropolitana, Chile
- DPdte. Riesco 6391-6399, Las Condes, Región Metropolitana, Chile
- EAv. Gral. Oscar Bonilla 418, Lo Prado, Región Metropolitana, Chile
- F
Santiago
Juan Esteban Montero 5688, Las Condes, Las Condes, Región Metropolitana, Chile
Compare bus companies
Based on 157 reviews, the company was rated 3.8 stars on Busbud. Travellers were especially satisfied with the cleanliness and the ticket access but often complained with the WiFi. Eme Bus ticket prices on this trip start at $17
Frequently asked questions about travelling from San Nicolás, CL to Santiago, CL by bus
What is the travel distance from San Nicolás to Santiago?
It's about 374 km (232 miles) from San Nicolás to Santiago.
What are the departure and arrival locations for buses traveling from San Nicolás to Santiago?
Buses departing from Terminal de Autobuses de San Nicolas in San Nicolás will take you to Terminal Sur in Santiago.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Nicolás, CL to Santiago, CL was searched and found on Nov 24, 2025 with a price of $17To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Nicolás, CL to Santiago, CL, as early as possible.
