Bus Tickets from San Nicolás, CL to Santiago, CL

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TodayJul 13
from US$14
TomorrowJul 14
TueJul 15
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Cheap buses leaving today

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: July 13 at
    Departure city: San Nicolás
    Departure location: Terminal de Autobuses de San Nicolas
    Arrival time: July 13 at
    Destination city: Santiago
    Destination location: Terminal Sur
    Operated by: EME BusEME Bus
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: July 13 at
    Departure city: San Nicolás
    Departure location: Terminal de Autobuses de San Nicolas
    Arrival time: July 13 at
    Destination city: Santiago
    Destination location: Terminal Sur
    Operated by: EME BusEME Bus
    Vehicle: BusDuration:
  • Departure time: July 13 at
    Departure city: San Nicolás
    Departure location: Terminal de Autobuses de San Nicolas
    Arrival time: July 13 at
    Destination city: Santiago
    Destination location: Terminal Sur
    Operated by: EME BusEME Bus
    Vehicle: BusDuration:
  • Departure time: July 13 at
    Departure city: San Nicolás
    Departure location: Terminal de Autobuses de San Nicolas
    Arrival time: July 13 at
    Destination city: Santiago
    Destination location: Terminal Sur
    Operated by: EME BusEME Bus
    Vehicle: BusDuration:

Last refresh of the prices: Yesterday at 10:28 AM -04.

Prices and availability are subject to change.

Accepted payments

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Bus San Nicolás to Santiago: Trip Overview

Average Ticket PriceUS$19
Average Bus Trip Duration4h 16m
Number of daily buses2
Earliest bus departure12:10am
Distance366 km
Latest bus departure2:30pm

San Nicolás to Santiago Bus

Busbud helps you find a bus from San Nicolás to Santiago. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from San Nicolás to Santiago.

Discover how much the bus trip from San Nicolás to Santiago will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip San Nicolás, CL - Santiago, CL

  1. What is the travel distance from San Nicolás to Santiago?

    It's about 374 km (232 miles) from San Nicolás to Santiago.

  2. What are the departure and arrival locations for buses traveling from San Nicolás to Santiago?

    Buses departing from Terminal de Autobuses de San Nicolas in San Nicolás will take you to Terminal Sur in Santiago.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
07-11
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07-12
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Today
US$12
07-14
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07-15
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07-16
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07-17
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07-18
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busbud logoThe cheapest trip from San Nicolás to Santiago was searched and found on Jul 13, 2025 with a price of US$12

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Nicolás to Santiago, as early as possible.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between San Nicolás and Santiago!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from San Nicolás to Santiago.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from San Nicolás to Santiago will emit less CO2 than a car or an airplane.

Tune out to the fine sounds of your best music playlist on your bus trip from San Nicolás to Santiago while indulging in miles on end of beautiful scenic views.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to San Nicolás by bus?

Bus from San Nicolás to Santiago

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