What is the travel distance from San Nicolás to Santiago?

San Nicolás and Santiago are 232 miles (374 km) apart.

What are the departure and arrival stations when taking the bus from San Nicolás to Santiago?

The majority of buses traveling from San Nicolás to Santiago start their journey at Terminal de Autobuses de San Nicolas and wind up at Terminal Sur. These are the most popular departure and arrival locations on this route, but you could find others that could be a better fit for your travel plans.

What are the best sights and things to do in Santiago?

Once in Santiago, you can start exploring the city and discover its surroundings. The top sights and things to do are Plaza de Armas, Cerro San Cristóbal, El Biógrafo, La Chascona House and Casablanca Valley Wine Tasting.

Bus San Nicolás to Santiago from $11 | Refundable Tickets

Next bus departures

Next departures for San Nicolás to Santiago on November 24
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	8:15am	Terminal de Autobuses de San Nicolas	4h 16m	12:31pm	Terminal Sur	Cheapest
Bus	2:30pm	Terminal de Autobuses de San Nicolas	4h 16m	6:46pm	Terminal Sur	Fastest
Bus	10:30am	Terminal de Autobuses de San Nicolas	4h 16m	2:46pm	Terminal Sur	No tags
Bus	10:30am	Terminal de Autobuses de San Nicolas	4h 16m	2:46pm	Terminal Sur	No tags
Bus	8:15am	Terminal de Autobuses de San Nicolas	4h 16m	12:31pm	Terminal Sur	No tags

Last refresh of the prices: Last Friday at 2:19 PM -03.

Get from San Nicolás to Santiago

This route is served by bus only

The journey takes about 4 hours 16 minutes and with fares starting at just $12, it presents an excellent value for a comfortable ride.

3bus per day

4h 16mAverage Duration

228 milesDistance

9kgCO₂ emissions

Where are the popular stops in San Nicolás and Santiago?

Stops in San Nicolás

A
Terminal de Autobuses de San Nicolas
N-50 312-448, San Nicolás, Región del Bío Bío, Chile
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Stops in Santiago

A
Terminal Sur
Santiago - Av Libertador Bernardo O'Higgins 3850, Santiago, Estación Central, Región Metropolitana, Chile
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B
San Borja
San Francisco de Borja 199-225, Santiago, Estación Central, Región Metropolitana, Chile
C
Terminal Los Héroes
Tucapel Jiménez 21, 8340528 Santiago, Región Metropolitana, Chile
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D
Terminal ETM
Pdte. Riesco 6391-6399, Las Condes, Región Metropolitana, Chile
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E
Pajaritos
Av. Gral. Oscar Bonilla 418, Lo Prado, Región Metropolitana, Chile
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F
Santiago
Juan Esteban Montero 5688, Las Condes, Las Condes, Región Metropolitana, Chile

Compare bus companies

Eme Bus

4/5157 reviews

Staff4.6

Timeliness4.4

Cleanliness4.8

Wifi2.9

Based on 157 reviews, the company was rated 3.8 stars on Busbud. Travelers were especially satisfied with the cleanliness and the ticket access but often complained with the wifi. Eme Bus ticket prices on this trip start at $12

CL bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about traveling from San Nicolás, CL to Santiago, CL by bus

What is the travel distance from San Nicolás to Santiago?
What are the departure and arrival stations when taking the bus from San Nicolás to Santiago?
What are the best sights and things to do in Santiago?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/22

$12

11/23

No data

Today

$12

11/25

No data

11/26

No data

11/27

No data

11/28

No data

11/29

No data

The cheapest trip from San Nicolás, CL to Santiago, CL was searched and found on Nov 24, 2025 with a price of $12

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Nicolás, CL to Santiago, CL, as early as possible.