Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Santander (Estacion de Autobuses) | Brussels South (Gare du Midi) | CheapestFastest | ||||
| Bus | Santander (Estacion de Autobuses) | Brussels North Train Station | No tags | ||||
| Bus | Santander (Estacion de Autobuses) | Brussels Airport | No tags |
Last refresh of the prices: Yesterday at 3:52 PM CET.
Compare 2 ways to travel from Santander to Brussels
Among the sustainable travel choices, the bus stands out as a good way to reach Brussels. The journey takes about 20 hours 45 minutes and with fares starting at just R 1 589, it presents an excellent value for a comfortable ride.
| Average price | Average duration | CO₂ emissions | Actions | |
|---|---|---|---|---|
| Average priceR 1 589 - R 1 750 | Average duration20h 45m | 26kg CO₂e | ||
Carpool | Average priceR 1 537 - R 1 537 | Average duration13h 20m | 43kg CO₂e |
Where are the popular stops in Santander and Brussels?
Stops in Santander
- ACalle Navas de Tolosa, 2, 39002 Santander, Cantabria, Spain
- B
Santander Airport
- C
Av. de los Castros 43A
Av. de los Castros 43A, 39005 Santander, Cantabria, Spain - D
Calle Camarreal-Ojaiz
Calle Camarreal-Ojaiz, 52, 39011 Santander, Cantabria, Spain - E
Av. de Pontejos
Av. de Pontejos, 33A, 39005 Santander, Cantabria, Spain - F
Estación Marítima
39002 Santander, Cantabria, Spain
Stops in Brussels
- ARue de France 85, 1060 Saint-Gilles, Belgium
- BBoulevard Simon Bolivar 7, 1030 Schaerbeek, Belgium
- CPachecolaan 5, 1000 Brussel, Belgium
- D
Centrale
Rue de Loxum 5, 1000 Bruxelles, Belgium
Compare bus companies
Based on 11824 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. FlixBus ticket prices on this trip start at R 1 589
Frequently asked questions about travelling from Santander to Brussels by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Santander to Brussels?
The cheapest bus tickets from Santander to Brussels start at R 1 589. The average price for this route is around R 1 589. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Santander to Brussels?
The average bus journey time from Santander to Brussels is 20h 45m, covering a distance of 1028 km. The fastest bus gets you there in 20h 20m and is operated by FlixBus.
Which bus companies service the Santander to Brussels route?
Several major bus companies operate on this route with 3 buses available per day.
What is the earliest and latest departure time for the bus from Santander to Brussels?
The earliest bus departs from Santander to Brussels at 18:50. And the latest bus departs at 18:50.
What are the CO₂ emissions for the bus trip from Santander to Brussels?
A bus trip from Santander to Brussels produces an estimated 26 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Santander to Brussels was searched and found on 31 Dec 2025 with a price of R 1 109To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santander to Brussels as early as possible.
