Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Santander (Estacion de Autobuses) | Brussels Airport BRU (Parking P14) | Cheapest | ||||
| Bus | Santander (Estacion de Autobuses) | Brussels South (Gare du Midi) | Fastest | ||||
| Bus | Santander (Estacion de Autobuses) | Brussels North Train Station | No tags | ||||
| Bus | Santander (Estacion de Autobuses) | Midi | No tags |
Last refresh of the prices: Yesterday at 9:29 PM CEST.
Get from Santander to Brussels
The journey takes about 20 hours 45 minutes, and with fares starting at just PEN 302, it presents an excellent value for a comfortable ride.
Bus stations and stops in Santander and Brussels
Stops in Santander
- A
Calle Navas de Tolosa, 2
Calle Navas de Tolosa, 2, 39002 Santander, Cantabria, Spain - C
Av. de los Castros 43A
Av. de los Castros 43A, 39005 Santander, Cantabria, Spain - D
Calle Camarreal-Ojaiz
Calle Camarreal-Ojaiz, 52, 39011 Santander, Cantabria, Spain - E
Av. de Pontejos
Av. de Pontejos, 33A, 39005 Santander, Cantabria, Spain - F
Estación Marítima
39002 Santander, Cantabria, Spain
Stops in Brussels
- A
Brussels South (Gare du Midi)
Rue de France 85, 1060 Saint-Gilles, Belgium - B
Brux-Nord
Boulevard Simon Bolivar 7, 1030 Schaerbeek, Belgium - C
Centrale
Rue de Loxum 5, 1000 Bruxelles, Belgium - D
Congrès
Pachecolaan 5, 1000 Brussel, Belgium
Compare bus companies
Based on 13016 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi‑Fi. FlixBus ticket prices on this trip start at PEN 340
Frequently asked questions about travelling from Santander to Brussels by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Santander to Brussels?
The cheapest bus tickets from Santander to Brussels start from PEN 302. The average price for this route is around PEN 485. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Santander to Brussels?
The average bus travel time from Santander to Brussels is 20h 45m, covering a distance of 1029 km. The quickest bus can get you there in 18h 45m and is operated by FlixBus.
Which bus companies service the Santander to Brussels route?
Several major bus companies operate on this route with 3 buses available per day.
What are the earliest and latest departure times for the bus from Santander to Brussels?
The earliest bus departs from Santander to Brussels at 6:00pm. And the latest bus departs at 6:55pm.
What are the CO₂ emissions for the bus trip from Santander to Brussels?
A bus trip from Santander to Brussels generates an estimated 25.7105 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Santander to Brussels was searched and found on Jul 15, 2026 with a price of PEN 366To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santander to Brussels, as early as possible.
You can expect to pay from PEN 366 to PEN 744 for a bus ticket from Santander to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at PEN 411 which is on 2026-07-17.
