Previously seen journeys
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Price and booking link |
|---|---|---|---|---|---|---|---|
 | Bus | Santander (Estacion de Autobuses) | Brussels South (Gare du Midi) | ||||
| Bus | Santander (Estacion de Autobuses) | Brussels North Train Station | ||||
| Bus | Santander (Estacion de Autobuses) | Brussels South (Gare du Midi) | ||||
| Bus | Santander (Estacion de Autobuses) | Midi | ||||
| Bus | Santander (Estacion de Autobuses) | Brussels Airport BRU |
Get from Santander to Brussels
The journey takes about 20 hours 45 minutes, and with fares starting at just CA$115, it presents an excellent value for a comfortable ride.
Bus stations and stops in Santander and Brussels
Stops in Santander
- A
Calle Navas de Tolosa, 2
Calle Navas de Tolosa, 2, 39002 Santander, Cantabria, Spain - C
Av. de los Castros 43A
Av. de los Castros 43A, 39005 Santander, Cantabria, Spain - D
Calle Camarreal-Ojaiz
Calle Camarreal-Ojaiz, 52, 39011 Santander, Cantabria, Spain - E
Av. de Pontejos
Av. de Pontejos, 33A, 39005 Santander, Cantabria, Spain - F
Estación Marítima
39002 Santander, Cantabria, Spain
Stops in Brussels
- A
Brussels South (Gare du Midi)
Rue de France 85, 1060 Saint-Gilles, Belgium - B
Brux-Nord
Boulevard Simon Bolivar 7, 1030 Schaerbeek, Belgium - C
Centrale
Rue de Loxum 5, 1000 Bruxelles, Belgium - D
Congrès
Pachecolaan 5, 1000 Brussel, Belgium
Compare bus companies
Based on 13099 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi‑Fi. FlixBus ticket prices on this trip start at CA$115
Frequently asked questions about travelling by bus from Santander to Brussels
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Santander to Brussels?
The cheapest coach tickets from Santander to Brussels start from CA$115. The average price for this route is around CA$178. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Santander to Brussels?
The average bus journey time from Santander to Brussels is 20h 45m, covering a distance of 638 miles. The fastest bus can take you there in 18h 45m and is operated by FlixBus.
Which bus companies service the Santander to Brussels route?
Several major bus companies operate on this route with 4 buses available per day.
What is the earliest and latest departure time for the bus from Santander to Brussels?
The earliest bus departs from Santander to Brussels at 18:00. And the latest bus departs at 18:55.
What are the CO₂ emissions for the bus trip from Santander to Brussels?
A bus journey from Santander to Brussels produces an estimated 25.700850000000003 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Santander to Brussels was searched and found on 28 Jul 2026 with a price of CA$109To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santander to Brussels as early as possible.
You can expect to pay from CA$109 to CA$173 for a bus ticket from Santander to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at CA$136, which is on 2026-07-31.
