Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Terminal Sur | Terminal de Autobuses de San Nicolas | CheapestFastest |
Last refresh of the prices: Yesterday at 11:51 AM -03.
Get from Santiago to San Nicolás
The journey takes about 4 hours 16 minutes, and with fares starting at just R 233, it presents an excellent value for a comfortable ride.
Where are the popular stops in Santiago and San Nicolás?
Stops in Santiago
- ASantiago - Av Libertador Bernardo O'Higgins 3850, Santiago, Estación Central, Región Metropolitana, Chile
- B
San Borja
San Francisco de Borja 199-225, Santiago, Estación Central, Región Metropolitana, Chile - CTucapel Jiménez 21, 8340528 Santiago, Región Metropolitana, Chile
- DPdte. Riesco 6391-6399, Las Condes, Región Metropolitana, Chile
- EAv. Gral. Oscar Bonilla 418, Lo Prado, Región Metropolitana, Chile
- F
Rancagua
Estado 480, Rancagua, VI Región, Chile
Stops in San Nicolás
- A
Terminal de Autobuses de San Nicolas
N-50 312-448, San Nicolás, Región del Bío Bío, Chile
Compare bus companies
Based on 157 reviews, the company was rated 3.8 stars on Busbud. Travellers were especially satisfied with the cleanliness and the ticket access but often complained about the Wi-Fi. Eme Bus ticket prices on this trip start at R 233
Frequently asked questions about travelling from Santiago, CL to San Nicolás, CL by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Santiago to San Nicolás?
The cheapest bus tickets from Santiago to San Nicolás start at R 233. The average price for this route is around R 288. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Santiago to San Nicolás?
The average bus journey time from Santiago to San Nicolás is 4h 16m, covering a distance of 367 km. The fastest bus gets you there in 4h 16m and is operated by Eme Bus.
Which bus companies service the Santiago to San Nicolás route?
Several major bus companies operate on this route with 4 buses available per day.
What is the earliest and latest departure time for the bus from Santiago to San Nicolás?
The earliest bus departs from Santiago to San Nicolás at 09:15. And the latest bus departs at 22:50.
What are the CO₂ emissions for the bus trip from Santiago to San Nicolás?
A bus trip from Santiago to San Nicolás produces an estimated 9 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Santiago, CL to San Nicolás, CL was searched and found on 16 Feb 2026 with a price of R 266To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago, CL to San Nicolás, CL as early as possible.
