Bus from Santiago, CL to Santa Cruz, CL: Tickets & Timetables

Next bus departures

Next departures from Santiago to Santa Cruz on 9 December
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
AndimarBus
    San Bernardo, Santiago (Cruce Colon)
    Terminal de Buses Santa CruzCheapestFastest
    Buses TranSantinBus
    Terminal Sur
    Terminal Santa CruzNo tags
    Buses Jet SurBus
    Terminal Sur
    Terminal Santa CruzNo tags
    AndimarBus
      San Bernardo, Santiago (Cruce Colon)
      Terminal de Buses Santa CruzNo tags
      Buses Jet SurBus
      Terminal Sur
      Terminal Santa CruzNo tags

      Last refresh of the prices: Today at 4:11 PM -03.

      Get from Santiago to Santa Cruz

      This route is served by bus only

      The journey takes about 2 hours 40 minutes, and with fares starting at just R 20, it presents an excellent value for a comfortable ride.

      37bus per day
      2h 40mAverage duration
      147 kmDistance
      4kgCO₂ emissions

      Frequently asked questions about travelling from Santiago, CL to Santa Cruz, CL by bus

      Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.

      1. How much is the bus ticket from Santiago to Santa Cruz?

        The cheapest bus tickets from Santiago to Santa Cruz start at R 20. The average price for this route is around R 127. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.

      2. How long is the bus journey from Santiago to Santa Cruz?

        The average bus journey time from Santiago to Santa Cruz is 2h 40m, covering a distance of 147 km. The fastest bus gets you there in 2h 25m and is operated by Buses Andimar.

      3. Which bus companies service the Santiago to Santa Cruz route?

        Several major bus companies operate on this route with 37 buses available per day, including services from Buses Andimar, buses TranSantin, Buses Jet Sur, Condor Bus, Pullman Tur.

      4. What is the earliest and latest departure time for the bus from Santiago to Santa Cruz?

        The earliest bus departs from Santiago to Santa Cruz at 06:10. And the latest bus departs at 21:14.

      5. What are the CO₂ emissions for the bus trip from Santiago to Santa Cruz?

        A bus trip from Santiago to Santa Cruz produces an estimated 4 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.

      6. What is the best bus company from Santiago to Santa Cruz?

        According to Busbud customers, the highest-rated bus company on this route is Buses Andimar, with an average rating of 4.2 out of 5 stars based on 55 reviews.

      7. Which bus company has the best Wi-Fi from Santiago to Santa Cruz?

        Based on reviews on Busbud, the bus company Pullman Tur has the best Wi-Fi rating with a score of 2.9.

      8. Which bus company offers the most punctual service from Santiago to Santa Cruz?

        According to Busbud traveller reviews, the most punctual bus company on this route is Buses Andimar, with a punctuality rating of 4.5 out of 5 stars.

      9. Which bus company has the cleanest buses from Santiago to Santa Cruz?

        According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Buses Andimar, with a cleanliness rating of 4.5 out of 5 stars.

      Find cheapest prices for buses

      Price is for a one-way ticket for one passenger and based on past searches.

      Best price found
      06/12
      R 121
      07/12
      R 117
      Today
      R 124
      09/12
      R 102
      10/12
      R 102
      11/12
      R 101
      12/12
      R 107
      13/12
      R 101
      busbud logoThe cheapest trip from Santiago, CL to Santa Cruz, CL was searched and found on 11 Dec 2025 with a price of R 101

      To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago, CL to Santa Cruz, CL as early as possible.

      You can expect to pay from R 101 to R 196 for a bus ticket from Santiago, CL to Santa Cruz, CL based on the last 2 days. You can expect to find the cheapest price for the trip at R 101, which is on 2025-12-11.

      Usually Buses Jet Sur will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

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