Find the cheapest bus tickets from Santiago to Santa Cruz

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Cheap buses leaving today

One passenger / one way

4:10 PM7:00 PM
$8
Santiago - SantiagoSanta Cruz - Terminal Santa Cruz
4:10 PM
Santiago - Santiago
7:00 PM
Santa Cruz - Terminal Santa Cruz
Nilahue
$8
5:10 PM8:00 PM
$8
Santiago - SantiagoSanta Cruz - Terminal Santa Cruz
5:10 PM
Santiago - Santiago
8:00 PM
Santa Cruz - Terminal Santa Cruz
Nilahue
$8
7:10 PM10:00 PM
$8
Santiago - SantiagoSanta Cruz - Terminal Santa Cruz
7:10 PM
Santiago - Santiago
10:00 PM
Santa Cruz - Terminal Santa Cruz
Nilahue
$8
4:10 PM7:00 PM
$8
Santiago - SantiagoSanta Cruz - Terminal Santa Cruz
4:10 PM
Santiago - Santiago
7:00 PM
Santa Cruz - Terminal Santa Cruz
Nilahue
$8

Cheap buses leaving Monday

One passenger / one way

1:10 PM4:00 PM
$8
Santiago - SantiagoSanta Cruz - Terminal Santa Cruz
1:10 PM
Santiago - Santiago
4:00 PM
Santa Cruz - Terminal Santa Cruz
Nilahue
$8
6:10 AM9:00 AM
$8
Santiago - SantiagoSanta Cruz - Terminal Santa Cruz
6:10 AM
Santiago - Santiago
9:00 AM
Santa Cruz - Terminal Santa Cruz
Nilahue
$8
7:40 AM10:30 AM
$8
Santiago - SantiagoSanta Cruz - Terminal Santa Cruz
7:40 AM
Santiago - Santiago
10:30 AM
Santa Cruz - Terminal Santa Cruz
Nilahue
$8
9:00 AM11:50 AM
$8
Santiago - SantiagoSanta Cruz - Terminal Santa Cruz
9:00 AM
Santiago - Santiago
11:50 AM
Santa Cruz - Terminal Santa Cruz
Nilahue
$8
10:10 AM1:00 PM
$8
Santiago - SantiagoSanta Cruz - Terminal Santa Cruz
10:10 AM
Santiago - Santiago
1:00 PM
Santa Cruz - Terminal Santa Cruz
Nilahue
$8
1:10 PM4:00 PM
$8
Santiago - SantiagoSanta Cruz - Terminal Santa Cruz
1:10 PM
Santiago - Santiago
4:00 PM
Santa Cruz - Terminal Santa Cruz
Nilahue
$8

Bus Santiago to Santa Cruz: Trip Overview

12
Daily Buses
5:40 AM - 8:10 PM
Earliest and Latest Bus Departures
$9
Average Ticket Price
Average Bus Trip Duration

Trip Reviews for Santiago - Santa Cruz

4.2 out of 5 stars

User reviews from travelers who booked a bus ticket from Santiago to Santa Cruz

Ratings and Reviews (5)


Peter T.February 1, 2020 | 

The two buses we were on were not well maintained on the interior nor set at a comfortable temperature. The staff was indifferent at best.

Amna S.December 7, 2019 | 

Overall great and would happily use this bus company again.

Rongrong P.May 17, 2019 | 

Need better explanation to locate the bus terminal

Joseph M.February 12, 2019 | 

Very soomth and safe ride.

Talita L.July 11, 2018 | 

Very precise service. Departure and arrival on time. Very comfortable bus!!

Santiago to Santa Cruz Buses

With Busbud, comparing and booking tickets for a bus from Santiago to Santa Cruz is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Santiago to Santa Cruz from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses traveling from Santiago to Santa Cruz, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Bus Companies

Bus travel from Santiago to Santa Cruz is made possible thanks to Nilahue.

Stations & Stops

Need a bus leaving from Santiago? Your starting point is at Terminal Sur, Terrapuerto Los Heroes, San Borja, San Borja, Terminal Sur, Pajaritos, Omnium, Terminal ETM, Terminal Sur or Pajaritos.

If you're onboard a bus traveling to Santa Cruz, you can get hop off at Terminal Santa Cruz or Santa Cruz.

Information on this bus route

Daily Buses12
Earliest and Latest Bus Departures5:40 AM - 8:10 PM
Minimum Price$7
Average Ticket Price$9
Minimum Trip Duration
Average Bus Trip Duration
Bus Companies on This RouteBuses Nilahue

Santiago to Santa Cruz Route Map

Santiago to Santa Cruz Route Map

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Santiago to Santa Cruz.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Santiago to Santa Cruz, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Santiago to Santa Cruz that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from Santiago to Santa Cruz while indulging in miles on end of beautiful scenic views.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Will you be returning to Santiago by bus?

If you are looking for the return bus journey, check out buses from Santa Cruz to Santiago.

Top travelled bus routes

Popular Buses Connecting Santiago

Popular Buses Connecting Santa Cruz

Popular routes in this country

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