- Santiago to Santa Cruz buses
Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
![]() | San Bernardo, Santiago (Cruce Colon) | Terminal de Buses Santa Cruz | CheapestFastest | |||||
![]() | Terminal Sur | Terminal Santa Cruz | No tags | |||||
![]() | Terminal Sur | Terminal Santa Cruz | No tags | |||||
![]() | San Bernardo, Santiago (Cruce Colon) | Terminal de Buses Santa Cruz | No tags | |||||
![]() | Terminal Sur | Terminal Santa Cruz | No tags |
Last refresh of the prices: Today at 4:35 PM -03.
Get from Santiago to Santa Cruz
The journey takes about 2 hours 40 minutes and with fares starting at just $4, it presents an excellent value for a comfortable ride.
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Where are the popular stops in Santiago and Santa Cruz?
Frequently asked questions about traveling from Santiago, CL to Santa Cruz, CL by bus
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago, CL to Santa Cruz, CL, as early as possible.
You can expect to pay from $7 to $14 for a bus ticket from Santiago, CL to Santa Cruz, CL based on the last 2 days. You can expect to find the cheapest price for the trip at $7 which is on 2025-11-09.
Usually Buses Jet Sur will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
Top traveled bus routes
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Popular Buses Connecting Santiago
Buses Leaving from Santiago
- Bus from Santiago to Antofagasta
- Bus Santiago - Mendoza
- Santiago - Temuco
- Bus from Santiago to Chillan
- Bus Santiago - Valdivia
- Santiago - Talca
- Bus from Santiago to Puerto Varas
- Bus Santiago - Santa Cruz
- Santiago - Casablanca
- Bus from Santiago to Concon
- Bus Santiago - San Antonio
- Santiago - Villarrica
- Bus from Santiago to Arica Province
- Bus Santiago - Los Angeles
- Santiago - Castro
Buses Going to Santiago
- Bus from Victoria to Santiago
- Bus Castro - Santiago
- Valdivia - Santiago
- Bus from Antofagasta to Santiago
- Bus San Felipe - Santiago
- Vina del Mar - Santiago
- Bus from Pichilemu to Santiago
- Bus Puerto Varas - Santiago
- Temuco - Santiago
- Bus from Santa Cruz to Santiago
- Bus Chillan - Santiago
- Arica Province - Santiago
- Bus from Talca to Santiago
- Bus San Antonio - Santiago
- Los Angeles - Santiago
Popular Buses Connecting Santa Cruz
Buses Leaving from Santa Cruz
Buses Going to Santa Cruz
Popular routes in this country
- Bus from Santiago to Valparaiso
- Bus Santiago - Pucon
- Valparaiso - Santiago
- Bus from Puerto Natales to Estancia Pudeto
- Bus Santiago - Pichilemu
- Puerto Montt - Santiago
- Bus from Pucon to Puerto Montt
- Bus Puerto Montt - Pucon
- Calama - Santiago
- Bus from Osorno Province to Pucon
- Bus Santiago - Vina del Mar
- Santiago - La Serena
- Bus from Concepción to Santiago
- Bus Puerto Varas - Pucon
- La Serena - Santiago











