Find coaches from La Serena, CL to Santiago, CL

Next departures

Next departures from La Serena to Santiago on 31 October
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Flixbus Chile
La Serena (Bus terminal La Serena)
Terminal San BorjaCheapest
Pullman San Andrés
Terminal de Buses La Serena
San BorjaFastest
Cikbus Elité
Terminal de Buses La Serena
Terminal de Buses San Borja - San Francisco de BorjaNo tags
Pluss Chile
Terminal de Buses La Serena
San BorjaNo tags
Paravias
Terminal de Buses La Serena
San BorjaNo tags

Last refresh of the prices: Today at 12:40 PM -03.

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Get from La Serena to Santiago

busbud logoThis route is served by bus only

The journey takes about 6 hours 20 minutes, and with fares starting at just US$3, it presents an excellent value for a comfortable ride.

68bus per day
6h 20mAverage duration
398 kmDistance
10kgCO₂ emissions

Bus La Serena, CL to Santiago, CL: Trip Overview

Average ticket priceUS$18
Average bus trip duration6h 20m
Number of daily buses68
Earliest bus departure00:05
Distance398 km
Latest bus departure23:59

La Serena to Santiago Bus

With Busbud, comparing and booking tickets for a bus from La Serena to Santiago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from La Serena to Santiago will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses travelling from La Serena to Santiago, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip La Serena, CL - Santiago, CL

  1. How much does a bus ticket from La Serena to Santiago cost?

    The bus ticket price from La Serena to Santiago starts at US$3. The best way to find cheap bus tickets from La Serena to Santiago is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from La Serena to Santiago?

    The average travel time between La Serena and Santiago is around 6h 20m, although the fastest bus will take about 5h 10m. This is the time it takes to travel the 398 km that separates the two cities.

  3. How many daily bus connections are there between La Serena and Santiago?

    The number of buses from La Serena to Santiago can differ depending on the day of the week. On average, there are 68 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from La Serena to Santiago by comparing and selecting the bus that fits your travel style and budget on Busbud.

  4. Which bus companies travel from La Serena to Santiago?

    When taking the bus from La Serena to Santiago, you can travel comfortably and safely with Pluss Chile, Cikbus Elité, FlixBus.

  5. What are the departure and arrival stations when taking the bus from La Serena to Santiago?

    Buses travelling between La Serena and Santiago leave from Terminal de Buses La Serena or Rotonda La Serena and arrive at San Borja, Terminal Sur, Terminal Los Héroes.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
28/10
US$13
29/10
US$20
Today
US$22
31/10
US$15
01/11
US$13
02/11
US$18
03/11
US$14
04/11
US$12
busbud logoThe cheapest trip from La Serena, CL to Santiago, CL was searched and found on 04 Nov 2025 with a price of US$12

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Serena, CL to Santiago, CL as early as possible.

You can expect to pay from US$12 to US$41 for a bus ticket from La Serena, CL to Santiago, CL based on the last 2 days. You can expect to find the cheapest price for the trip at US$12, which is on 2025-11-04.

Usually Pullman San Andres, Pluss Chile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from La Serena to Santiago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from La Serena to Santiago, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from La Serena to Santiago that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from La Serena to Santiago, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Will you be returning to La Serena, CL by bus?

Bus from Santiago, CL to La Serena, CL

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