Based on 86 reviews, the company was rated 3.9 stars on Busbud. Travellers were especially satisfied with the departure location and the seats but often complained with the Wi-Fi. Pluss Chile ticket prices on this trip start at R 172
Based on 11610 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the Wi-Fi. FlixBus ticket prices on this trip start at R 148
According to 12 reviews, Cikbus Elité received a 3.6-star rating for this journey. Travellers were especially satisfied with the staff and the seats, but some complained about the timeliness. Cikbus Elité ticket prices on this trip start at R 161
Based on 55 reviews, the company was rated 4.2 stars on Busbud. Travellers were especially satisfied with the ticket access and the seats but often complained with the Wi-Fi. Buses Andimar ticket prices on this trip start at R 189
Andimar La Serena Santiago recent customer reviews
Based on 13 reviews, the company was rated 3.6 stars on Busbud. Travellers were especially satisfied with the seats and the temperature but often complained with the timeliness. Pullman San Andres ticket prices on this trip start at R 249
Based on 53 reviews, the company was rated 3.8 stars on Busbud. Travellers were especially satisfied with the departure location and the ticket access but often complained with the Wi-Fi. Buses Romani ticket prices on this trip start at R 163
Buses Romani La Serena Santiago recent customer reviews
Based on 70 reviews, the company was rated 3 stars on Busbud. Travellers were especially satisfied with the timeliness and the departure location but often complained with the Wi-Fi. Buses Paravias ticket prices on this trip start at R 252
Paravias La Serena Santiago recent customer reviews
I had selected an upstairs aisle seat and ended up in a cramped downstairs window seat. Uncomfortable and no place to put personal belongings.
Based on 12 reviews, Serena Mar was rated 4 stars for this trip. Serena Mar ticket prices on this trip start at R 249, with the trip lasting on average 370.
Serena Mar La Serena Santiago recent customer reviews
A good way to travel this route is with Turisnorte buses. The company offers 1 daily departures, with ticket prices starting at R 383 and the shortest trip taking about 435. Turisnorte gets you where you want to go for a fair price.
Based on 19 reviews, Condor Bus was rated 3.6 stars for this trip. Condor Bus ticket prices on this trip start at R 256, with the trip lasting on average 397.
Based on 3 reviews, the company was rated 4.3 stars on Busbud. Travellers were especially satisfied with the staff and the timeliness but often complained with the Wi-Fi. Clikbus ticket prices on this trip start at R 296
Frequently asked questions about travelling from La Serena, CL to Santiago, CL by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from La Serena to Santiago?
The cheapest bus tickets from La Serena to Santiago start at R 148. The average price for this route is around R 333. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from La Serena to Santiago?
The average bus journey time from La Serena to Santiago is 6h 30m, covering a distance of 399 km. The fastest bus gets you there in 5h 10m and is operated by Clikbus.
Which bus companies service the La Serena to Santiago route?
What is the earliest and latest departure time for the bus from La Serena to Santiago?
The earliest bus departs from La Serena to Santiago at 00:05. And the latest bus departs at 23:59.
What are the CO₂ emissions for the bus trip from La Serena to Santiago?
A bus trip from La Serena to Santiago produces an estimated 10 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
What is the best bus company from La Serena to Santiago?
According to Busbud customers, the highest-rated bus company on this route is Clikbus, with an average rating of 4.3 out of 5 stars based on 3 reviews.
Which bus company has the best Wi-Fi from La Serena to Santiago?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company offers the most punctual service from La Serena to Santiago?
According to Busbud traveller reviews, the most punctual bus company on this route is Clikbus, with a punctuality rating of 5.0 out of 5 stars.
Which bus company has the cleanest buses from La Serena to Santiago?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Buses Andimar, with a cleanliness rating of 4.5 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
12/12
R 312
13/12
R 312
Today
R 307
15/12
R 175
16/12
R 140
17/12
R 175
18/12
R 175
19/12
R 175
The cheapest trip from La Serena, CL to Santiago, CL was searched and found on 16 Dec 2025 with a price of R 140
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Serena, CL to Santiago, CL as early as possible.
You can expect to pay from R 140 to R 701 for a bus ticket from La Serena, CL to Santiago, CL based on the last 2 days. You can expect to find the cheapest price for the trip at R 140, which is on 2025-12-16.
Usually Pluss Chile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
The cheapest trip from La Serena, CL to Santiago, CL was searched and found on 16 Dec 2025 with a price of R 140
