Find coaches from Syracuse, US to Chicago

Next departures

Next departures from Syracuse to Chicago on 31 October
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
Syracuse (Regional Transportation Center)
Downtown Greyhound StationCheapest
Greyhound Lines, Inc.
Syracuse (Regional Transportation Center)
Downtown Greyhound StationFastest
Greyhound Lines, Inc.
Syracuse (Regional Transportation Center)
Downtown Greyhound StationNo tags
Greyhound Lines, Inc. + FlixBus
Syracuse (Regional Transportation Center)
Chicago 95Th & Dan RyanNo tags
Greyhound Lines, Inc.
Syracuse (Regional Transportation Center)
537-517 W. Jackson BlvdNo tags

Last refresh of the prices: Today at 7:43 AM EDT.

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Compare 2 ways to travel from Syracuse to Chicago

busbud logoWe recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Chicago. The journey takes about 1 day, 5 hours and with fares starting at just US$57, it presents an excellent value for a comfortable ride.

9bus per day
1d 5hAverage duration
952 kmDistance
24kgCO₂ emissions
Bus
Average priceUS$57 - US$232Average duration1d 5h
24kg CO₂e
Train
Average priceUS$60 - US$215Average duration13h 7m
86kg CO₂e

Bus Syracuse, US to Chicago: Trip Overview

Average ticket priceUS$100
Average bus trip duration1d 5h
Number of daily buses9
Earliest bus departure02:00
Distance952 km
Latest bus departure21:00

Syracuse to Chicago Bus

Busbud helps you find a bus from Syracuse to Chicago. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from Syracuse to Chicago from the most reliable bus companies operating this trip.

Discover how much the bus trip from Syracuse to Chicago will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Syracuse, US - Chicago

  1. How much does a bus ticket from Syracuse to Chicago cost?

    The bus ticket price from Syracuse to Chicago starts at US$57. The best way to find cheap bus tickets from Syracuse to Chicago is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from Syracuse to Chicago?

    The average travel time between Syracuse and Chicago is around 1d 5h, although the fastest bus will take about 16h 35m. This is the time it takes to travel the 954 km that separates the two cities.

  3. How many daily bus connections are there between Syracuse and Chicago?

    The number of buses from Syracuse to Chicago can differ depending on the day of the week. On average, there are 9 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Syracuse to Chicago by comparing and selecting the bus that fits your travel style and budget on Busbud.

  4. Which bus companies travel from Syracuse to Chicago?

    When taking the bus from Syracuse to Chicago, you can travel comfortably and safely with Greyhound, FlixBus, New York Trailways.

  5. What are the departure and arrival stations when taking the bus from Syracuse to Chicago?

    Buses travelling between Syracuse and Chicago leave from Regional Transportation Center or Syracuse Airport and arrive at Downtown Greyhound Station, Chicago O'Hare International Airport, Polk St & Canal St.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
28/10
US$50
29/10
US$165
Today
US$182
31/10
US$108
01/11
US$87
02/11
US$91
03/11
US$74
04/11
US$71
busbud logoThe cheapest trip from Syracuse, US to Chicago was searched and found on 28 Oct 2025 with a price of US$50

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Chicago as early as possible.

You can expect to pay from US$50 to US$205 for a bus ticket from Syracuse, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at US$71, which is on 2025-11-04.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Syracuse and Chicago!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Syracuse to Chicago, get comfy and count the stars.

Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Syracuse to Chicago will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Syracuse to Chicago.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

What's the cheapest way to go from Syracuse, US to Chicago?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Syracuse, US by bus?

Bus from Chicago to Syracuse, US

You can also go to Chicago by train

Train from Syracuse, US to Chicago

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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