Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Syracuse (Regional Transportation Center) | Chicago 95Th & Dan Ryan | Cheapest | ||||
 | Bus | Syracuse (Regional Transportation Center) | Downtown Greyhound Station | Fastest | ||||
| Bus | Syracuse (Regional Transportation Center) | Downtown Greyhound Station | No tags | ||||
| Bus | Syracuse (Regional Transportation Center) | 537-517 W. Jackson Blvd | No tags | ||||
| Bus | Syracuse (Regional Transportation Center) | Chicago 95Th & Dan Ryan | No tags |
Last refresh of the prices: Yesterday at 10:50 PM EDT.
Compare 2 ways to travel from Syracuse to Chicago
Among the sustainable travel choices, the Train stands out as a good way to reach Chicago. The journey takes about 13 hours 7 minutes and with fares starting at just PEN 209, it presents an excellent value for a comfortable ride.
Where are the popular stops in Syracuse and Chicago?
Stops in Syracuse
- A
Regional Transportation Center
1 Walsh Circle Ste 30, Syracuse, NY 13208 - CBus stops at Schine Student Center across the street from the Sheraton Parking Garage., Schine Student Center, 303 University Pl, Syracuse, NY 13210
- D
Syracuse University - Lyman Hall
College Place, Syracuse, NY 13210, USA - E
New York State Fairgrounds
581 State Fair Blvd, Syracuse, NY 13209, USA - F
Syracuse, NY
349-399 US-11, Syracuse, NY 13202, USA
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Compare bus companies
Frequently asked questions about travelling from Syracuse, US to Chicago by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Syracuse to Chicago?
The cheapest bus tickets from Syracuse to Chicago start at PEN 223. The average price for this route is around PEN 315. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Syracuse to Chicago?
The average bus journey time from Syracuse to Chicago is 1d 1h, covering a distance of 952 km. The fastest bus gets you there in 15h 25m and is operated by Greyhound.
Which bus companies service the Syracuse to Chicago route?
What is the earliest and latest departure time for the bus from Syracuse to Chicago?
The earliest bus departs from Syracuse to Chicago at 03:20. And the latest bus departs at 21:00.
What are the CO₂ emissions for the bus trip from Syracuse to Chicago?
A bus trip from Syracuse to Chicago produces an estimated 23.79575 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
What is the best bus company from Syracuse to Chicago?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87532 reviews.
Which bus company has the best Wi-Fi from Syracuse to Chicago?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company offers the most punctual service from Syracuse to Chicago?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Syracuse to Chicago?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Syracuse, US to Chicago was searched and found on 22 Apr 2026 with a price of PEN 327To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Chicago as early as possible.
You can expect to pay from PEN 327 to PEN 748 for a bus ticket from Syracuse, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at PEN 327, which is on 2026-04-22.
What's the cheapest way to go from Syracuse, US to Chicago?
The Bus is the cheapest travel choice for this destination
