Next bus departures

Next departures from Syracuse to Chicago on 18 April
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	19:35	Syracuse (Regional Transportation Center)	18h 50m	13:25	Chicago 95Th & Dan Ryan	Cheapest
	Bus	19:35	Syracuse (Regional Transportation Center)	15h 25m	10:00	Downtown Greyhound Station	Fastest
	Bus	04:30	Syracuse (Regional Transportation Center)	16h 35m	20:05	Downtown Greyhound Station	No tags
	Bus	04:30	Syracuse (Regional Transportation Center)	1d 4h	08:00	537-517 W. Jackson Blvd	No tags
	Bus	04:30	Syracuse (Regional Transportation Center)	20h 5m	23:35	Chicago 95Th & Dan Ryan	No tags

Last refresh of the prices: Yesterday at 10:50 PM EDT.

Compare 2 ways to travel from Syracuse to Chicago

We recommend taking the train

Among the sustainable travel choices, the Train stands out as a good way to reach Chicago. The journey takes about 13 hours 7 minutes and with fares starting at just CZK 1 248, it presents an excellent value for a comfortable ride.

1train per day

13h 7mAverage duration

950 kmDistance

86kgCO₂ emissions

	Average price	Average duration	CO₂ emissions	Actions
Bus	Average priceCZK 1 479 - CZK 8 932	Average duration1d 1h	CO₂ emissions 24kg CO₂e
Train	Average priceCZK 1 248 - CZK 4 565	Average duration13h 7m	CO₂ emissions 86kg CO₂e

Where are the popular stops in Syracuse and Chicago?

Stops in Syracuse

A
Regional Transportation Center
1 Walsh Circle Ste 30, Syracuse, NY 13208
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B
Syracuse Airport
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C
Syracuse University
Bus stops at Schine Student Center across the street from the Sheraton Parking Garage., Schine Student Center, 303 University Pl, Syracuse, NY 13210
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D
Syracuse University - Lyman Hall
College Place, Syracuse, NY 13210, USA
E
New York State Fairgrounds
581 State Fair Blvd, Syracuse, NY 13209, USA
F
Syracuse, NY
349-399 US-11, Syracuse, NY 13202, USA

Stops in Chicago

A
Downtown Greyhound Station
630 W Harrison St, Chicago, IL 60607, USA
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B
Chicago O'Hare International Airport
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C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA
D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA
E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA
F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

15/04

CZK 2 993

16/04

CZK 3 331

Today

CZK 3 489

18/04

CZK 3 404

19/04

CZK 2 920

20/04

CZK 2 161

21/04

CZK 2 066

22/04

CZK 1 950

The cheapest trip from Syracuse, US to Chicago was searched and found on 22 Apr 2026 with a price of CZK 1 950

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Chicago as early as possible.

You can expect to pay from CZK 1 950 to CZK 4 469 for a bus ticket from Syracuse, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at CZK 1 950, which is on 2026-04-22.