How much is the bus ticket from Syracuse to Chicago?

The cheapest bus tickets from Syracuse to Chicago start from $72. The average price for this route is around $91. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from Syracuse to Chicago?

The average bus trip duration from Syracuse to Chicago is 1d 5h, covering a distance of 591 miles (952 km). The quickest bus can get you there in 16h 35m and is operated by Greyhound .

Which bus companies service the Syracuse to Chicago route?

Several major bus companies operate on this route with 10 buses available per day, including services from Greyhound , FlixBus , New York Trailways , Adirondack Trailways .

What is the earliest and latest departure time for the bus from Syracuse to Chicago?

The earliest bus departs from Syracuse to Chicago at 3:20am. And the latest bus departs at 9:00pm.

What are the CO₂ emissions for the bus trip from Syracuse to Chicago?

A bus trip from Syracuse to Chicago generates an estimated 24 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

What is the best bus company from Syracuse to Chicago?

According to Busbud customers, the highest-rated bus company on this route is Adirondack Trailways , with an average rating of 4.1 out of 5 stars based on 1148 reviews.

Which bus company has the best Wi-Fi from Syracuse to Chicago?

Based on reviews on Busbud, the bus company New York Trailways has the best Wi-Fi rating with a score of 3.1.

Which bus company has the most timely service from Syracuse to Chicago?

According to Busbud traveler reviews, the most timely bus company on this route is Adirondack Trailways , with a punctuality rating of 4.3 out of 5 stars.

Which bus company has the cleanest buses from Syracuse to Chicago?

According to Busbud traveler reviews, the bus company with the cleanest buses on this route is Adirondack Trailways , with a cleanliness rating of 4.7 out of 5 stars.

Bus Syracuse to Chicago from $76 | Refundable Tickets

Next bus departures

More dates

Next departures for Syracuse to Chicago on February 21
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	2:00pm	Syracuse (Regional Transportation Center)	1d 10h	11:35pm	Chicago 95Th & Dan Ryan	Cheapest
	Bus	4:30am	Syracuse (Regional Transportation Center)	16h 35m	8:05pm	Downtown Greyhound Station	Fastest
	Bus	9:25am	Syracuse (Regional Transportation Center)	1d 1h	10:00am	Downtown Greyhound Station	No tags
FlixBus + Greyhound Lines, Inc.	Bus	2:00pm	Syracuse (Regional Transportation Center)	1d 7h	8:05pm	Downtown Greyhound Station	No tags
	Bus	4:30am	Syracuse (Regional Transportation Center)	1d 4h	8:00am	537-517 W. Jackson Blvd	No tags

Last refresh of the prices: Today at 9:44 AM EST.

View all departures

Compare 2 ways to go from Syracuse to Chicago

We recommend taking the train

Among the sustainable travel choices, the Train stands out as a good way to reach Chicago. The journey takes about 13 hours 7 minutes and with fares starting at just $60, it presents an excellent value for a comfortable ride.

1train per day

13h 7mAverage Duration

589 milesDistance

86kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$72 - $315	Average Duration1d 5h	CO₂ emissions 24kg CO₂e
Train	Average Price$60 - $215	Average Duration13h 7m	CO₂ emissions 86kg CO₂e

Where are the popular stops in Syracuse and Chicago?

Stops in Syracuse

A
Regional Transportation Center
1 Walsh Circle Ste 30, Syracuse, NY 13208
Visit page
B
Syracuse Airport
Visit page
C
Syracuse University
Bus stops at Schine Student Center across the street from the Sheraton Parking Garage., Schine Student Center, 303 University Pl, Syracuse, NY 13210
Visit page
D
Syracuse University - Lyman Hall
College Place, Syracuse, NY 13210, USA
E
New York State Fairgrounds
581 State Fair Blvd, Syracuse, NY 13209, USA
F
Syracuse, NY
349-399 US-11, Syracuse, NY 13202, USA

Stops in Chicago

A
Downtown Greyhound Station
630 W Harrison St, Chicago, IL 60607, USA
Visit page
B
Chicago O'Hare International Airport
Visit page
C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA
D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA
E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA
F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA

Compare bus companies

Greyhound

3.5/587,523 reviews

Staff3.6

Timeliness2.9

Cleanliness3.4

Wifi2.5

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

FlixBus

3.5/512,235 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

New York Trailways

4/54,431 reviews

Staff4.6

Timeliness4.1

Cleanliness4.5

Wifi3.2

Trailways is a network of over 70 bus companies that focus on providing quality bus rides at affordable prices all over the US since 1936. Among the most famous affiliates are Trailways of New York, Pine Hill Trailways, Adirondack Trailways and Burlington Trailways. Trailways buses have WiFi, power outlets, bathrooms, air conditioning, overhead lighting, and reclinable seats with footrests. You can find two different types of Trailway fares: saver and flexible. Saver tickets are non-refundable, while flexible tickets are fully reimbursed up to one hour before travel time. If you're traveling with them, don't forget to print your boarding pass and show a valid photo ID to board the bus.

Adirondack Trailways

4/51,150 reviews

Staff4.6

Timeliness4.3

Cleanliness4.7

Wifi2.3

US bus companies:FlixBus, Greyhound, BlaBlaCar Bus, ALSA, Intercape, Trenitalia, Big Sky

Frequently asked questions about traveling from Syracuse, US to Chicago by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Syracuse to Chicago?
The cheapest bus tickets from Syracuse to Chicago start from $72. The average price for this route is around $91. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Syracuse to Chicago?
The average bus trip duration from Syracuse to Chicago is 1d 5h, covering a distance of 591 miles (952 km). The quickest bus can get you there in 16h 35m and is operated by Greyhound.
Which bus companies service the Syracuse to Chicago route?
Several major bus companies operate on this route with 10 buses available per day, including services from Greyhound, FlixBus, New York Trailways, Adirondack Trailways.
What is the earliest and latest departure time for the bus from Syracuse to Chicago?
The earliest bus departs from Syracuse to Chicago at 3:20am. And the latest bus departs at 9:00pm.
What are the CO₂ emissions for the bus trip from Syracuse to Chicago?
A bus trip from Syracuse to Chicago generates an estimated 24 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Syracuse to Chicago?
According to Busbud customers, the highest-rated bus company on this route is Adirondack Trailways, with an average rating of 4.1 out of 5 stars based on 1148 reviews.
Which bus company has the best Wi-Fi from Syracuse to Chicago?
Based on reviews on Busbud, the bus company New York Trailways has the best Wi-Fi rating with a score of 3.1.
Which bus company has the most timely service from Syracuse to Chicago?
According to Busbud traveler reviews, the most timely bus company on this route is Adirondack Trailways, with a punctuality rating of 4.3 out of 5 stars.
Which bus company has the cleanest buses from Syracuse to Chicago?
According to Busbud traveler reviews, the bus company with the cleanest buses on this route is Adirondack Trailways, with a cleanliness rating of 4.7 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

02/18

$186

02/19

$180

Today

$166

02/21

$181

02/22

$188

02/23

$92

02/24

$138

02/25

$126

The cheapest trip from Syracuse, US to Chicago was searched and found on Feb 23, 2026 with a price of $92

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Chicago, as early as possible.

You can expect to pay from $92 to $217 for a bus ticket from Syracuse, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $92 which is on 2026-02-23.