Bus Tickets from Syracuse, US to Chicago

Next bus departures

Next departures for Syracuse to Chicago on November 20
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc.Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound StationCheapestFastest
Greyhound Lines, Inc.Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound StationNo tags
FlixBus + Greyhound Lines, Inc.
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound StationNo tags
Greyhound Lines, Inc.Bus
Syracuse (Regional Transportation Center)
537-517 W. Jackson BlvdNo tags
Greyhound Lines, Inc. + FlixBus
Bus
Syracuse (Regional Transportation Center)
Chicago 95Th & Dan RyanNo tags

Last refresh of the prices: Yesterday at 10:29 PM EST.

Compare 2 ways to go from Syracuse to Chicago

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Chicago. The journey takes about 1 day, 5 hours, and with fares starting at just $81, it presents an excellent value for a comfortable ride.

9bus per day
1d 5hAverage Duration
952 kmDistance
24kgCO₂ emissions
Bus
Average Price$81 - $452Average Duration1d 5h
24kg CO₂e
Train
Average Price$86 - $309Average Duration13h 7m
86kg CO₂e

Frequently asked questions about travelling from Syracuse, US to Chicago by bus

  1. What is the travel distance from Syracuse to Chicago?

    The distance covered from Syracuse to Chicago is 954 km (592 miles).

  2. What are the departure and arrival locations for buses traveling from Syracuse to Chicago?

    Buses traveling this route start their trip at Regional Transportation Center, in Syracuse, and end it at Downtown Greyhound Station, in Chicago.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
11-17
$178
11-18
$183
Today
$178
11-20
$185
11-21
$168
11-22
$235
11-23
$228
11-24
$228
busbud logoThe cheapest trip from Syracuse, US to Chicago was searched and found on Nov 21, 2025 with a price of $168

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Chicago, as early as possible.

You can expect to pay from $168 to $437 for a bus ticket from Syracuse, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $168 which is on 2025-11-21.

What's the cheapest way to go from Syracuse, US to Chicago?

busbud logoThe bus is the cheapest travel choice for this destination

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