Next departures from Syracuse to Chicago on 19 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
CheapestFastest
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
No tags
Greyhound Lines, Inc. + FlixBus
Bus
Syracuse (Regional Transportation Center)
Chicago 95Th & Dan Ryan
No tags
Bus
Syracuse (Regional Transportation Center)
537-517 W. Jackson Blvd
No tags
Bus
Syracuse (Regional Transportation Center)
Chicago 95Th & Dan Ryan
No tags
Next departures from Syracuse to Chicago on 20 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
Cheapest
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
Fastest
FlixBus + Greyhound Lines, Inc.
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
No tags
Bus
Syracuse (Regional Transportation Center)
537-517 W. Jackson Blvd
No tags
Bus
Syracuse (Regional Transportation Center)
Chicago 95Th & Dan Ryan
No tags
Next departures from Syracuse to Chicago on 21 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
CheapestFastest
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
No tags
Bus
Syracuse (Regional Transportation Center)
537-517 W. Jackson Blvd
No tags
Greyhound Lines, Inc. + FlixBus
Bus
Syracuse (Regional Transportation Center)
Chicago 95Th & Dan Ryan
No tags
Next departures from Syracuse to Chicago on 22 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Greyhound Lines, Inc. + FlixBus
Bus
Syracuse (Regional Transportation Center)
Chicago 95Th & Dan Ryan
Cheapest
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
Fastest
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
No tags
Bus
Syracuse (Regional Transportation Center)
537-517 W. Jackson Blvd
No tags
Next departures from Syracuse to Chicago on 23 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Syracuse (Regional Transportation Center)
Chicago 95Th & Dan Ryan
Cheapest
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
Fastest
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
No tags
Bus
Syracuse (Regional Transportation Center)
537-517 W. Jackson Blvd
No tags
Next departures from Syracuse to Chicago on 24 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
CheapestFastest
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
No tags
Bus
Syracuse (Regional Transportation Center)
537-517 W. Jackson Blvd
No tags
Greyhound Lines, Inc. + FlixBus
Bus
Syracuse (Regional Transportation Center)
Chicago 95Th & Dan Ryan
No tags
Next departures from Syracuse to Chicago on 25 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Syracuse (Regional Transportation Center)
Chicago 95Th & Dan Ryan
Cheapest
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
Fastest
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
No tags
Bus
Syracuse (Regional Transportation Center)
537-517 W. Jackson Blvd
No tags
Last refresh of the prices: Today at 22:46 EST.
Compare 2 ways to travel from Syracuse to Chicago
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as a good way to reach Chicago. The journey takes about 1 day, 5 hours and with fares starting at just £44, it presents an excellent value for a comfortable ride.
Based on 87378 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. Greyhound ticket prices on this trip start at £44
Based on 11358 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. FlixBus ticket prices on this trip start at £80
Based on 4412 reviews, the company was rated 3.9 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the Wi-Fi. New York Trailways ticket prices on this trip start at £274
Based on 1125 reviews, the company was rated 4.1 stars on Busbud. Travellers were especially satisfied with the ticket access and the cleanliness but often complained with the Wi-Fi. Adirondack Trailways ticket prices on this trip start at £274
Bus stops at Schine Student Center across the street from the Sheraton Parking Garage., Schine Student Center, 303 University Pl, Syracuse, NY 13210Syracuse University
Frequently asked questions about travelling by bus from Syracuse, US to Chicago
How far is Chicago from Syracuse by coach?
The distance between Syracuse and Chicago by coach is approximately 592 miles (954 km).
Is there a way to reach Chicago from Syracuse without flying?
You have the option to select the coach for your journey on this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You also have the option of utilising carpooling services.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
15/11
£104
16/11
£106
Today
£97
18/11
£99
19/11
£92
20/11
£80
21/11
£121
22/11
£122
The cheapest trip from Syracuse, US to Chicago was searched and found on 20 Nov 2025 with a price of £80
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Chicago as early as possible.
You can expect to pay from £80 to £177 for a bus ticket from Syracuse, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at £80, which is on 2025-11-20.
What's the cheapest way to go from Syracuse, US to Chicago?
The bus is the cheapest travel choice for this destination
The cheapest trip from Syracuse, US to Chicago was searched and found on 20 Nov 2025 with a price of £80
The bus is the cheapest travel choice for this destination
