Next departures from Syracuse to Chicago on 3 December
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
Cheapest
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
Fastest
Bus
Syracuse (Regional Transportation Center)
537-517 W. Jackson Blvd
No tags
Greyhound Lines, Inc. + FlixBus
Bus
Syracuse (Regional Transportation Center)
Chicago 95Th & Dan Ryan
No tags
Bus
Syracuse (Regional Transportation Center)
537-517 W. Jackson Blvd
No tags
Next departures from Syracuse to Chicago on 4 December
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Syracuse (Regional Transportation Center)
537-517 W. Jackson Blvd
Cheapest
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
Fastest
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
No tags
Bus
Syracuse (Regional Transportation Center)
537-517 W. Jackson Blvd
No tags
Next departures from Syracuse to Chicago on 7 December
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
CheapestFastest
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
No tags
Bus
Syracuse (Regional Transportation Center)
537-517 W. Jackson Blvd
No tags
Greyhound Lines, Inc. + FlixBus
Bus
Syracuse (Regional Transportation Center)
Chicago 95Th & Dan Ryan
No tags
Next departures from Syracuse to Chicago on 8 December
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
Cheapest
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
Fastest
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
No tags
Greyhound Lines, Inc. + FlixBus
Bus
Syracuse (Regional Transportation Center)
Chicago 95Th & Dan Ryan
No tags
Bus
Syracuse (Regional Transportation Center)
537-517 W. Jackson Blvd
No tags
Next departures from Syracuse to Chicago on 9 December
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Syracuse (Regional Transportation Center)
Chicago 95Th & Dan Ryan
Cheapest
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
Fastest
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Syracuse (Regional Transportation Center)
Downtown Greyhound Station
No tags
Bus
Syracuse (Regional Transportation Center)
537-517 W. Jackson Blvd
No tags
Last refresh of the prices: Today at 22:38 EST.
Compare 2 ways to travel from Syracuse to Chicago
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as a good way to reach Chicago. The journey takes about 1 day, 5 hours and with fares starting at just £47, it presents an excellent value for a comfortable ride.
Based on 87412 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. Greyhound ticket prices on this trip start at £47
Based on 11492 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the Wi-Fi. FlixBus ticket prices on this trip start at £80
Based on 4417 reviews, the company was rated 3.9 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the Wi-Fi. New York Trailways ticket prices on this trip start at £273
Based on 1129 reviews, the company was rated 4.1 stars on Busbud. Travellers were especially satisfied with the ticket access and the cleanliness but often complained with the Wi-Fi. Adirondack Trailways ticket prices on this trip start at £273
Frequently asked questions about travelling by bus from Syracuse, US to Chicago
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Syracuse to Chicago?
The cheapest coach tickets from Syracuse to Chicago start from £47. The average price for this route is around £90. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Syracuse to Chicago?
The average bus journey time from Syracuse to Chicago is 1d 5h, covering a distance of 591 miles. The fastest bus can take you there in 16h 35m and is operated by Greyhound.
Which bus companies service the Syracuse to Chicago route?
What is the earliest and latest departure time for the bus from Syracuse to Chicago?
The earliest bus departs from Syracuse to Chicago at 01:15. And the latest bus departs at 21:00.
What are the CO₂ emissions for the bus trip from Syracuse to Chicago?
A bus journey from Syracuse to Chicago produces an estimated 24 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Which is the best bus company from Syracuse to Chicago?
According to Busbud customers, the highest-rated bus company on this route is Adirondack Trailways, with an average rating of 4.1 out of 5 stars based on 1126 reviews.
Which company has the best Wi-Fi from Syracuse to Chicago?
Based on Busbud reviews, the bus company New York Trailways has the best Wi-Fi rating with a score of 3.1.
Which bus company offers the most punctual service from Syracuse to Chicago?
According to Busbud traveller reviews, the most punctual bus company on this route is Adirondack Trailways, with a punctuality rating of 4.3 out of 5 stars.
Which bus company has the cleanest buses from Syracuse to Chicago?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Adirondack Trailways, with a cleanliness rating of 4.8 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
29/11
£179
30/11
£235
Today
£127
02/12
£120
03/12
£99
04/12
£82
05/12
£106
06/12
£77
The cheapest trip from Syracuse, US to Chicago was searched and found on 6 Dec 2025 with a price of £77
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Chicago as early as possible.
You can expect to pay from £77 to £330 for a bus ticket from Syracuse, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at £77, which is on 2025-12-06.
What's the cheapest way to go from Syracuse, US to Chicago?
The bus is the cheapest travel choice for this destination