Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Terminal Bus Palermo | Siena Train Station | CheapestFastest | ||||
| Bus | Terminal Bus Palermo | Siena Train Station | No tags | ||||
| Bus | Terminal Bus Palermo | Viale Toselli (Penny Market) | No tags | ||||
| Bus | Terminal Bus Palermo | Viale Toselli (Penny Market) | No tags | ||||
| Bus | Terminal Bus Palermo | Piazza Gramsci | No tags |
Last refresh of the prices: Yesterday at 3:42 PM CEST.
Get from Palermo to Siena
The journey takes about 19 hours 50 minutes and with fares starting at just PEN 248, it presents an excellent value for a comfortable ride.
Where are the popular stops in Palermo and Siena?
Stops in Palermo
- AVia Tommaso Fazello, 16, 90123 Palermo PA, Italy
- BPunta Raisi, 90145, Palermo
- CPiazza Cairoli, 8-14, 90123 Palermo, Italy
- D90143 Palermo PA, Italy
- E
Via Paolo Balsamo, 31
Via Paolo Balsamo, 23-31, 90123 Palermo, Italy - F
Piazza Ruggero Settimo, 12
Piazza Ruggero Settimo, 12C, 90139 Palermo, Italy
Stops in Siena
- APiazza Antonio Gramsci, 53100 Siena SI, Italy
- B
Via Sallustio Bandini, 21
Via Sallustio Bandini, 21, 53100 Siena SI, Italy - C
Via Giuseppe Mazzini, 58
Via Giuseppe Mazzini, 58, 53100 Siena SI, Italy - D
Via Riccardo Lombardi, 42
Via Riccardo Lombardi, 42, 53100 Siena SI, Italy - E
Torre Fiorentina
Torre Fiorentina, 53100 Siena SI, Italy - F
Siena Zona Industriale
Siena FS, 53100 Siena SI, Italy
Compare bus companies
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Palermo to Siena by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Palermo to Siena?
The cheapest bus tickets from Palermo to Siena start from PEN 248. The average price for this route is around PEN 372. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Palermo to Siena?
The average bus trip duration from Palermo to Siena is 19h 50m, covering a distance of 375 miles (605 km). The quickest bus can get you there in 16h 20m and is operated by FlixBus.
Which bus companies service the Palermo to Siena route?
Several major bus companies operate on this route with 5 buses available per day.
What is the earliest and latest departure time for the bus from Palermo to Siena?
The earliest bus departs from Palermo to Siena at 3:25pm. And the latest bus departs at 9:10pm.
What are the CO₂ emissions for the bus trip from Palermo to Siena?
A bus trip from Palermo to Siena generates an estimated 15.115475 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Palermo to Siena was searched and found on May 25, 2026 with a price of PEN 262To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Palermo to Siena, as early as possible.
You can expect to pay from PEN 262 to PEN 750 for a bus ticket from Palermo to Siena based on the last 2 days. You can expect to find the cheapest price for the trip at PEN 262 which is on 2026-05-25.
