Previously seen trips

Next departures for Chicago to Florence on August 3
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location
Greyhound + FlixBus	Bus	6:40pm	Chicago 95Th & Dan Ryan	1d 4h	12:05am	Florence, SC
Greyhound + FlixBus	Bus	10:00pm	537-517 W. Jackson Blvd	1d 6h	5:45am	Florence, SC
FlixBus + Greyhound	Bus	10:30pm	Chicago 95Th & Dan Ryan	1d 6h	5:45am	Florence, SC
FlixBus + Greyhound	Bus	11:15pm	Downtown Greyhound Station	1d 5h	5:45am	Florence, SC
FlixBus + Greyhound	Bus	10:00pm	537-517 W. Jackson Blvd	1d 13h	12:45pm	Bus station

Compare 2 ways to go from Chicago to Florence

We recommend taking the bus

Among the sustainable travel choices, the Bus stands out as a good way to reach Florence. The journey takes about 1 day, 5 hours 34 minutes and with fares starting at just PEN 292, it presents an excellent value for a comfortable ride.

10bus per day

1d 5hAverage Duration

677 milesDistance

27kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average PricePEN 292 - PEN 1,252	Average Duration1d 5h	CO₂ emissions 27kg CO₂e
Train	Average PricePEN 947 - PEN 1,663	Average Duration1d 7h	CO₂ emissions 100kg CO₂e

Bus stations and stops in Chicago and Florence

Stops in Chicago

A
Downtown Greyhound Station
630 W Harrison St, Chicago, IL 60607, USA
Visit page
B
Chicago O'Hare International Airport
Visit page
C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA
D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA
E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA
F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA

Stops in Florence

A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA
Visit page
B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA

Compare bus companies

Greyhound

3.5/587,591 reviews

Staff3.6

Timeliness2.9

Cleanliness3.4

Wifi2.5

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

FlixBus

3.5/513,140 reviews

Staff4.2

Timeliness4.0

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

US bus companies:FlixBus, Greyhound, Futura, Elite, Chihuahuenses, Tufesa, Adirondack Trailways

Frequently asked questions about traveling from Chicago to Florence, SC, US by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Chicago to Florence?
The cheapest bus tickets from Chicago to Florence start from PEN 292. The average price for this route is around PEN 496. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Chicago to Florence?
The average bus trip duration from Chicago to Florence is 1d 5h, covering a distance of 677 miles (1092 km). The quickest bus can get you there in 1d 1h and is operated by Greyhound.
Which bus companies service the Chicago to Florence route?
Several major bus companies operate on this route with 10 buses available per day, including services from Greyhound, FlixBus.
What is the earliest and latest departure time for the bus from Chicago to Florence?
The earliest bus departs from Chicago to Florence at 5:25am. And the latest bus departs at 11:55pm.
What are the CO₂ emissions for the bus trip from Chicago to Florence?
A bus trip from Chicago to Florence generates an estimated 27.284249999999997 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Chicago to Florence?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87588 reviews.
Which bus company has the best Wi-Fi from Chicago to Florence?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Chicago to Florence?
According to Busbud traveler reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Chicago to Florence?
According to Busbud traveler reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

08/01

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08/02

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Today

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08/04

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08/05

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08/06

PEN 397

08/07

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08/08

PEN 423

The cheapest trip from Chicago to Florence, SC, US was searched and found on Aug 6, 2026 with a price of PEN 397

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Florence, SC, US, as early as possible.

You can expect to pay from PEN 397 to PEN 423 for a bus ticket from Chicago to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at PEN 397 which is on 2026-08-06.