Bus from Chicago to Florence, SC, US: Tickets & Schedules

Previously seen trips

Next departures for Chicago to Florence on March 6
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound + FlixBus
Bus
537-517 W. Jackson Blvd
Florence, SCNo tags
Greyhound + FlixBus
Bus
Downtown Greyhound Station
Florence, SCNo tags
Greyhound + FlixBus
Bus
Chicago 95Th & Dan Ryan
Florence, SCNo tags
Greyhound + FlixBus
Bus
Chicago 95Th & Dan Ryan
Florence, SCNo tags
FlixBus + Greyhound
Bus
Downtown Greyhound Station
Florence, SCNo tags

Compare 2 ways to go from Chicago to Florence

We recommend taking the bus

Among the sustainable travel choices, the Bus stands out as a good way to reach Florence. The journey takes about 1 day, 2 hours 30 minutes and with fares starting at just $108, it presents an excellent value for a comfortable ride.

10bus per day
1d 2hAverage Duration
681 milesDistance
27kgCO₂ emissions
Average Price$108 - $279Average Duration1d 2h
27kg CO₂e
Average Price$217 - $429Average Duration1d 7h
100kg CO₂e

Frequently asked questions about traveling from Chicago to Florence, SC, US by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

  1. How much is the bus ticket from Chicago to Florence?

    The cheapest bus tickets from Chicago to Florence start from $108. The average price for this route is around $176. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

  2. How long is the bus ride from Chicago to Florence?

    The average bus trip duration from Chicago to Florence is 1d 2h, covering a distance of 681 miles (1098 km). The quickest bus can get you there in 1d 2h and is operated by Greyhound.

  3. Which bus companies service the Chicago to Florence route?

    Several major bus companies operate on this route with 10 buses available per day, including services from Greyhound, FlixBus.

  4. What is the earliest and latest departure time for the bus from Chicago to Florence?

    The earliest bus departs from Chicago to Florence at 5:25am. And the latest bus departs at 11:50pm.

  5. What are the CO₂ emissions for the bus trip from Chicago to Florence?

    A bus trip from Chicago to Florence generates an estimated 27 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

  6. What is the best bus company from Chicago to Florence?

    According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87524 reviews.

  7. Which bus company has the best Wi-Fi from Chicago to Florence?

    Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.

  8. Which bus company has the most timely service from Chicago to Florence?

    According to Busbud traveler reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.

  9. Which bus company has the cleanest buses from Chicago to Florence?

    According to Busbud traveler reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
03/04
No data
03/05
$185
Today
No data
03/07
No data
03/08
No data
03/09
No data
03/10
No data
03/11
No data
busbud logoThe cheapest trip from Chicago to Florence, SC, US was searched and found on Mar 5, 2026 with a price of $185

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Florence, SC, US, as early as possible.

What's the cheapest way to go from Chicago to Florence, SC, US?

busbud logoThe Bus is the cheapest travel choice for this destination

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