How much does a train ticket from Chicago to Greenville cost?

The average train ticket price from Chicago to Greenville is $368. The best way to find train tickets from Chicago to Greenville is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

How long is the train trip from Chicago to Greenville?

A train trip between Chicago and Greenville is around 1d 9h, although the fastest train will take about 1d 9h. This is the time it takes to travel the 561 miles that separates the two cities.

How many daily trains are there between Chicago and Greenville?

The number of trains from Chicago to Greenville can differ depending on the day of the week. On average, there is 1. Some trains are direct while others have layovers. Simplify your train trip from Chicago to Greenville by comparing and selecting the train that fits you travel style and budget on Busbud.

Which train companies travel from Chicago to Greenville?

When taking the train from Chicago to Greenville, you can travel comfortably and safely with Amtrak.

Train Chicago to Greenville from $1,072 | Refundable Tickets

Next train departures

Next departures for Chicago to Greenville on November 25
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Train	5:55pm	Chicago (Union Station), IL	1d 10h	5:24am	Greenville Station	Cheapest
	Train	6:40pm	Chicago (Union Station), IL	1d 9h	5:24am	Greenville Station	Fastest

Last refresh of the prices: Last Wednesday at 10:27 PM CST.

Compare 2 ways to go from Chicago to Greenville

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as the good way to reach Greenville. The journey takes about 20 hours 50 minutes and with fares starting at just $96, it presents an excellent value for a comfortable ride.

13bus per day

20h 50mAverage Duration

565 milesDistance

23kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$96 - $390	Average Duration20h 50m	CO₂ emissions 23kg CO₂e
Train	Average Price$217 - $1,437	Average Duration1d 9h	CO₂ emissions 82kg CO₂e

Train Companies

Amtrak

4/55,604 reviews

Staff4.7

Timeliness3.8

Cleanliness4.6

Wifi3.6

Based on 5604 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the seats and the ticket access but often complained with the wifi. Amtrak ticket prices on this trip start at $217

Train and bus companies in US:Amtrak, Trenitalia, Renfe, VIA Rail Canada, Amtrak Acela, NS Nederlandse Spoorwegen, Iryo

Frequently asked questions about traveling from Chicago to Greenville, SC by train

How much does a train ticket from Chicago to Greenville cost?
How long is the train trip from Chicago to Greenville?
How many daily trains are there between Chicago and Greenville?
Which train companies travel from Chicago to Greenville?

Find cheapest prices for trains

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/22

$397

11/23

No data

Today

No data

11/25

$1,072

11/26

No data

11/27

No data

11/28

No data

11/29

No data

The cheapest trip from Chicago to Greenville, SC was searched and found on Nov 22, 2025 with a price of $397

To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Chicago to Greenville, SC, as early as possible.

You can expect to pay from $397 to $1,387 for a train ticket from Chicago to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $1,072 which is on 2025-11-25.