Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Südseite Hauptbahnhof | Brussels North Train Station | Cheapest | ||||
| Bus | Südseite Hauptbahnhof | Brussels North Train Station | Fastest | ||||
 | Bus | Karlsruhe | Brussels-South (Gare du Midi) | No tags | ||||
| Bus | Südseite Hauptbahnhof | Brussels Airport | No tags | ||||
| Bus | Südseite Hauptbahnhof | Brussels Airport | No tags |
Last refresh of the prices: Yesterday at 9:44 PM CET.
Compare 3 ways to go from Karlsruhe to Brussels
Among the sustainable travel choices, the carpool stands out as a good way to reach Brussels. The journey takes about 4 hours 30 minutes, and with fares starting at just $34, it presents an excellent value for a comfortable ride.
Where are the popular stops in Karlsruhe and Brussels?
Stops in Karlsruhe
- AHinterm Hauptbahnhof 6, 76137 Karlsruhe, Germany
- BBahnhofpl. 1A, 76137 Karlsruhe, Germany
- CGoethestraße 17-19, 76135 Karlsruhe, Germany
- D
Karlsruhe
Gartenstraße 58, 76135 Karlsruhe, Germany - E
Karlsruhe/Baden-Baden Airport
Quebec Avenue, 77836 Rheinmünster, Germany
Stops in Brussels
- ARue de France 85, 1060 Saint-Gilles, Belgium
- BBoulevard Simon Bolivar 7, 1030 Schaerbeek, Belgium
- CPachecolaan 5, 1000 Brussel, Belgium
- D
Centrale
Rue de Loxum 5, 1000 Bruxelles, Belgium
Compare bus companies
Frequently asked questions about travelling from Karlsruhe to Brussels by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Karlsruhe to Brussels?
The cheapest bus tickets from Karlsruhe to Brussels start from $36. The average price for this route is around $78. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Karlsruhe to Brussels?
The average bus travel time from Karlsruhe to Brussels is 11h 40m, covering a distance of 357 km. The quickest bus can get you there in 7h 30m and is operated by FlixBus.
Which bus companies service the Karlsruhe to Brussels route?
Several major bus companies operate on this route with 2 buses available per day, including services from FlixBus, BlaBlaCar Bus.
What are the earliest and latest departure times for the bus from Karlsruhe to Brussels?
The earliest bus departs from Karlsruhe to Brussels at 12:25am. And the latest bus departs at 11:10pm.
What are the CO₂ emissions for the bus trip from Karlsruhe to Brussels?
A bus trip from Karlsruhe to Brussels generates an estimated 9 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Karlsruhe to Brussels?
According to Busbud customers, the highest-rated bus company on this route is BlaBlaCar Bus, with an average rating of 3.7 out of 5 stars based on 11239 reviews.
Which bus company has the best Wi-Fi from Karlsruhe to Brussels?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Karlsruhe to Brussels?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Karlsruhe to Brussels?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is BlaBlaCar Bus, with a cleanliness rating of 4.3 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Karlsruhe to Brussels was searched and found on Dec 20, 2025 with a price of $72To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Karlsruhe to Brussels, as early as possible.
You can expect to pay from $72 to $324 for a bus ticket from Karlsruhe to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at $94 which is on 2025-12-25.
