Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Penco | Terminal Sur | Cheapest | ||||
| Bus | Penco | Terminal Sur | Fastest | ||||
| Bus | Penco | Terminal Sur | No tags | ||||
| Bus | Penco | Terminal Sur | No tags | ||||
| Bus | Penco | Terminal Sur | No tags |
Last refresh of the prices: Last Sunday at 9:03 AM -03.
Get from Penco to Santiago
The journey takes about 5 hours 6 minutes, and with fares starting at just $22, it presents an excellent value for a comfortable ride.
Where are the popular stops in Penco and Santiago?
Stops in Penco
- A
Terminal de Autobuses de Penco
Ruta 150 9, Penco, Región del Bío Bío, Chile
Stops in Santiago
- ASantiago - Av Libertador Bernardo O'Higgins 3850, Santiago, Estación Central, Región Metropolitana, Chile
- B
San Borja
San Francisco de Borja 199-225, Santiago, Estación Central, Región Metropolitana, Chile - CTucapel Jiménez 21, 8340528 Santiago, Región Metropolitana, Chile
- DPdte. Riesco 6391-6399, Las Condes, Región Metropolitana, Chile
- EAv. Gral. Oscar Bonilla 418, Lo Prado, Región Metropolitana, Chile
- F
Santiago
Juan Esteban Montero 5688, Las Condes, Las Condes, Región Metropolitana, Chile
Compare bus companies
Based on 157 reviews, the company was rated 3.8 stars on Busbud. Travellers were especially satisfied with the cleanliness and the ticket access but often complained with the WiFi. Eme Bus ticket prices on this trip start at $22
Frequently asked questions about travelling from Penco to Santiago, CL by bus
How far is Penco from Santiago?
The distance between Penco and Santiago is approximately 429 km (266 miles).
What are the departure and arrival locations for buses traveling from Penco to Santiago?
Buses departing from Terminal de Autobuses de Penco in Penco will take you to Terminal Sur in Santiago.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Penco to Santiago, CL was searched and found on Nov 28, 2025 with a price of $20To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Penco to Santiago, CL, as early as possible.
You can expect to pay from $20 to $38 for a bus ticket from Penco to Santiago, CL based on the last 2 days. You can expect to find the cheapest price for the trip at $20 which is on 2025-11-28.
