Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Rome Tiburtina Bus Station | Alessandria | CheapestFastest | ||||
 | Bus | Rome Tiburtina Bus Station | Alessandria | No tags |
Last refresh of the prices: Today at 12:14 AM CET.
Compare 3 ways to go from Rome to Alessandria
Among the sustainable travel choices, the carpool stands out as a good way to reach Alessandria. The journey takes about 5 hours 40 minutes, and with fares starting at just $75, it presents an excellent value for a comfortable ride.
Where are the popular stops in Rome and Alessandria?
Stops in Rome
- ALargo Guido Mazzoni, 3, 00162 Roma, Italy
- D
Castro Pretorio
Viale Castro Pretorio 76, 00185 Roma, Italy - E
Roma
- F
Anagnina
Via Vincenzo Giudice, 00173 Roma RM, Italy
Stops in Alessandria
- APiazza Eugenio Curiel, 15121 Alessandria
- B
Fermata dell'autobus Alessandria
Strada Alessandria 42, 15122 Alessandria AL, Italy
Compare bus companies
Frequently asked questions about travelling from Rome to Alessandria by bus
What is the travel distance from Rome to Alessandria?
The distance between Rome and Alessandria is approximately 459 km (285 miles).
What are the departure and arrival locations for buses traveling from Rome to Alessandria?
Buses departing from Rome Tiburtina Bus Station in Rome will take you to Alessandria in Alessandria.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Rome to Alessandria was searched and found on Nov 26, 2025 with a price of $61To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Rome to Alessandria, as early as possible.
You can expect to pay from $61 to $117 for a bus ticket from Rome to Alessandria based on the last 2 days. You can expect to find the cheapest price for the trip at $61 which is on 2025-11-26.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
