Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Rome Tiburtina Bus Station | Terminal Interbus | No tags | ||||
| Bus | Rome Anagnina | Terminal Interbus | No tags | ||||
| Bus | Rome Fiumicino Airport | Terminal Interbus | No tags | ||||
| Bus | Aeroporto Ciampino Airport (CIA) | Terminal Interbus | No tags | ||||
| Bus | Rome Tiburtina Bus Station | Terminal Interbus | No tags |
Compare 3 ways to go from Rome to Syracuse
Among the sustainable travel choices, the carpool stands out as a good way to reach Syracuse. The journey takes about 9 hours 30 minutes, and with fares starting at just $64, it presents an excellent value for a comfortable ride.
Where are the popular stops in Rome and Syracuse?
Stops in Rome
- BLargo Guido Mazzoni, 3, 00162 Roma, Italy
- D
Castro Pretorio
Viale Castro Pretorio 76, 00185 Roma, Italy - E
Roma
- F
Anagnina
Via Vincenzo Giudice, 00173 Roma RM, Italy
Stops in Syracuse
- AViale Paolo Orsi, 20, 96100 Siracusa SR, Italy
- B
Siracusa
Piazzale della Stazione Centrale, 21, 96100 Siracusa SR, Italy - C
Siracusa - Terminal Bus (Stazione FS)
Viale Teocrito, 68-74, 96100 Siracusa SR, Italy
Compare bus companies
Based on 11388 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the WiFi. FlixBus ticket prices on this trip start at $53
Frequently asked questions about travelling from Rome to Syracuse by bus
How far is Rome from Syracuse?
It's about 588 km (365 miles) from Rome to Syracuse.
What are the departure and arrival locations for buses traveling from Rome to Syracuse?
Buses traveling this route start their trip at Rome Ciampino Airport, in Rome, and end it at Fermata dell'autobus Siracusa, in Syracuse.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Rome to Syracuse was searched and found on Nov 25, 2025 with a price of $63To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Rome to Syracuse, as early as possible.
You can expect to pay from $63 to $238 for a bus ticket from Rome to Syracuse based on the last 2 days. You can expect to find the cheapest price for the trip at $63 which is on 2025-11-25.
