Previously seen journeys
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Rome Tiburtina Bus Station | Terminal Interbus | No tags | ||||
| Bus | Rome Anagnina | Terminal Interbus | No tags | ||||
| Bus | Rome Fiumicino Airport | Terminal Interbus | No tags | ||||
| Bus | Aeroporto Ciampino Airport (CIA) | Terminal Interbus | No tags | ||||
| Bus | Rome Tiburtina Bus Station | Terminal Interbus | No tags |
Compare 3 ways to travel from Rome to Syracuse
Among the sustainable travel choices, the carpool stands out as a good way to reach Syracuse. The journey takes about 9 hours 30 minutes and with fares starting at just £35, it presents an excellent value for a comfortable ride.
Where are the popular stops in Rome and Syracuse?
Stops in Rome
- BLargo Guido Mazzoni, 3, 00162 Roma, Italy
- D
Castro Pretorio
Viale Castro Pretorio 76, 00185 Roma, Italy - E
Roma
- F
Anagnina
Via Vincenzo Giudice, 00173 Roma RM, Italy
Stops in Syracuse
- AViale Paolo Orsi, 20, 96100 Siracusa SR, Italy
- B
Siracusa
Piazzale della Stazione Centrale, 21, 96100 Siracusa SR, Italy - C
Siracusa - Terminal Bus (Stazione FS)
Viale Teocrito, 68-74, 96100 Siracusa SR, Italy
Compare bus companies
Based on 11387 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the Wi-Fi. FlixBus ticket prices on this trip start at £29
Frequently asked questions about travelling by bus from Rome to Syracuse
What's the distance between Rome and Syracuse by coach?
The distance between Rome and Syracuse by coach is approximately 365 miles (588 km).
How can I travel from Rome to Syracuse avoiding air travel?
You can choose the coach to travel this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You also have the option of utilising carpooling services.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Rome to Syracuse was searched and found on 25 Nov 2025 with a price of £34To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Rome to Syracuse as early as possible.
You can expect to pay from £34 to £129 for a bus ticket from Rome to Syracuse based on the last 2 days. You can expect to find the cheapest price for the trip at £34, which is on 2025-11-25.
