Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Aeroporto Ciampino Airport (CIA) | Terminal Interbus | Cheapest | ||||
| Bus | Rome Tiburtina Bus Station | Terminal Interbus | Fastest | ||||
| Bus | Rome Fiumicino Airport | Terminal Interbus | No tags |
Last refresh of the prices: Yesterday at 10:18 AM CEST.
Compare 2 ways to go from Rome to Syracuse
Among the sustainable travel choices, the Train stands out as a good way to reach Syracuse. The journey takes about 11 hours 11 minutes and with fares starting at just CHF 65, it presents an excellent value for a comfortable ride.
Where are the popular stops in Rome and Syracuse?
Stops in Rome
- A
Termini
Piazza dei Cinquecento 1, 00185 Roma RM, Italy - B
Rome Tiburtina Bus Station
Largo Guido Mazzoni, 3, 00162 Roma, Italy - C
Rome Fiumicino Airport (FCO), Train station
Fiumicino Aeroporto, 00054 Fiumicino RM, Italy - D
Roma S. Pietro
Roma S.Pietro, 00165 Roma RM, Italy - E
Roma Trastevere
Roma Trastevere Railway Station, 00152 Roma RM, Italy
Stops in Syracuse
- A
S. Teresa Longarini
Via Elorina, 129, 96100 Siracusa SR, Italy - B
Fermata dell'autobus Siracusa
Viale Paolo Orsi, 20, 96100 Siracusa SR, Italy - C
Siracusa
Piazzale della Stazione Centrale, 21, 96100 Siracusa SR, Italy - D
Siracusa - Terminal Bus (Stazione FS)
Viale Teocrito, 68-74, 96100 Siracusa SR, Italy
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Frequently asked questions about traveling from Rome to Syracuse by bus or train
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is a ticket from Rome to Syracuse?
The cheapest tickets from Rome to Syracuse start from CHF 44. The average price for this route is around CHF 77. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the ride from Rome to Syracuse?
The average trip duration from Rome to Syracuse is 16h 35m, covering a distance of 364 miles (586 km). The quickest vehicle can get you there in 11h 11m and is operated by Trenitalia.
Which companies service the Rome to Syracuse route?
Several major companies operate on this route with 1 trips available per day, including services from FlixBus, Trenitalia.
What is the earliest and latest departure time from Rome to Syracuse?
The earliest trip departs from Rome to Syracuse at 7:26am. And the latest trip departs at 11:55pm.
What are the CO₂ emissions for the trip from Rome to Syracuse?
A trip from Rome to Syracuse generates an estimated 14.637274999999999 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best company from Rome to Syracuse?
According to Busbud customers, the highest-rated company on this route is Trenitalia, with an average rating of 4.0 out of 5 stars based on 59 reviews.
Which company has the best Wi-Fi from Rome to Syracuse?
Based on reviews on Busbud, the company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which company has the most timely service from Rome to Syracuse?
According to Busbud traveler reviews, the most timely company on this route is Trenitalia, with a punctuality rating of 4.6 out of 5 stars.
Which company has the cleanest vehicles from Rome to Syracuse?
According to Busbud traveler reviews, the company with the cleanest vehicles on this route is Trenitalia, with a cleanliness rating of 4.7 out of 5 stars.
Find cheapest prices for buses and trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Rome to Syracuse was searched and found on Jun 8, 2026 with a price of CHF 44To save money and be sure you have the best seat, it's a good idea to buy your bus and train tickets from Rome to Syracuse, as early as possible.
You can expect to pay from CHF 44 to CHF 110 for a bus or train ticket from Rome to Syracuse based on the last 2 days. You can expect to find the cheapest price for the trip at CHF 47 which is on 2026-06-10.
Usually Trenitalia will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
