Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Gasolinera Puma Los Naranjos | Hotel las Americas | Cheapest | |||||
| Gasolinera Puma Los Naranjos | Metroplaza Guatemala | Fastest | |||||
| Fertica Santa Ana | Hotel las Americas | No tags | |||||
 | Gasolinera Puma | Holiday Inn Guatemala City | No tags | |||||
| Fertica Santa Ana | Hotel las Americas | No tags |
Last refresh of the prices: Yesterday at 2:14 PM CST.
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Bus Santa Ana, SV to Guatemala City: Trip Overview
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Santa Ana to Guatemala City Bus
Busbud helps you find a bus from Santa Ana to Guatemala City. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.
We make it our job to connect you with the most dependable bus companies that cover bus service from Santa Ana to Guatemala City.
From cheap bus tickets to more luxurious buses travelling from Santa Ana to Guatemala City, we offer a wide range of bus services to best suit your needs depending on how much your budget is.
Frequently asked questions on the trip Santa Ana, SV - Guatemala City
What is the travel distance from Santa Ana to Guatemala City?
It's about 126 km (78 miles) from Santa Ana to Guatemala City.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Santa Ana, SV to Guatemala City was searched and found on Oct 11, 2025 with a price of US$35To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santa Ana, SV to Guatemala City, as early as possible.
You can expect to pay from US$35 to US$100 for a bus ticket from Santa Ana, SV to Guatemala City based on the last 2 days. You can expect to find the cheapest price for the trip at US$35 which is on 2025-10-14.
About Bus Travel
Bus Travel Tips
Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Santa Ana and Guatemala City!
From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Santa Ana to Guatemala City.
Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Santa Ana to Guatemala City that are otherwise impossible to come by with a plane.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Santa Ana to Guatemala City.
Did you know?
Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!
Top travelled bus routes
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Popular Buses Connecting Santa Ana
Buses Leaving from Santa Ana
Buses Going to Santa Ana
Popular Buses Connecting Guatemala City
Buses Leaving from Guatemala City
- Bus from Guatemala City to San José
- Bus Guatemala City - EL AMATILLO
- Guatemala City - León
- Bus from Guatemala City to Tipitapa
- Bus Guatemala City - Esteli
- Guatemala City - Nandaime
- Bus from Guatemala City to La Union
- Bus Guatemala City - Orotina
- Guatemala City - San Miguel
- Bus from Guatemala City to Rivas
- Bus Guatemala City - Chinandega
- Guatemala City - Ocotal
- Bus from Guatemala City to Choluteca
- Bus Guatemala City - La Libertad
- Guatemala City - Sébaco
Buses Going to Guatemala City
- Bus from Managua to Guatemala City
- Bus Izabal - Guatemala City
- San Miguel - Guatemala City
- Bus from Sébaco to Guatemala City
- Bus La Union - Guatemala City
- Tipitapa - Guatemala City
- Bus from EL AMATILLO to Guatemala City
- Bus Ocotal - Guatemala City
- Esteli - Guatemala City
- Bus from San Isidro to Guatemala City
- Bus Choluteca - Guatemala City
- La Libertad - Guatemala City