Bus Tickets from St. Louis to Lexington, KY

Next departures

Next departures for St. Louis to Lexington on October 24
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc.
Gateway Station
WJW Investments Bus StopCheapestFastest
Greyhound Lines, Inc.
Gateway Station
WJW Investments Bus StopNo tags

Last refresh of the prices: Yesterday at 10:28 AM CDT.

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Bus St. Louis to Lexington, KY: Trip Overview

Average Ticket PriceUS$67
Average Bus Trip Duration12h 20m
Number of daily buses2
Earliest bus departure2:00am
Distance503 km
Latest bus departure11:30pm

St. Louis to Lexington Bus

Busbud helps you find a bus from St. Louis to Lexington. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from St. Louis to Lexington from the most reliable bus companies operating this trip.

Discover how much the bus trip from St. Louis to Lexington will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip St. Louis - Lexington, KY

  1. What is the travel distance from St. Louis to Lexington?

    It's about 504 km (313 miles) from St. Louis to Lexington.

  2. What are the departure and arrival locations for buses traveling from St. Louis to Lexington?

    Buses departing from Gateway Station in St. Louis will take you to WJW Investments Bus Stop in Lexington.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10-16
No data
10-17
US$43
Today
US$91
10-19
No data
10-20
No data
10-21
No data
10-22
No data
10-23
No data
busbud logoThe cheapest trip from St. Louis to Lexington, KY was searched and found on Oct 17, 2025 with a price of US$43

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Lexington, KY, as early as possible.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between St. Louis and Lexington!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from St. Louis to Lexington, get comfy and count the stars.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from St. Louis to Lexington will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from St. Louis to Lexington.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Will you be returning to St. Louis by bus?

Bus from Lexington, KY to St. Louis

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