Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Flixbus Chile + Andimar | Bus | Talca (Cruce Varoli) | La Serena (Bus terminal La Serena) | CheapestFastest |
Last refresh of the prices: Today at 12:43 AM -03.
Get from Talca to La Serena
The journey takes about 11 hours, and with fares starting at just $25, it presents an excellent value for a comfortable ride.
Where are the popular stops in Talca and La Serena?
Stops in Talca
- ADos Sur / Doce y Trece Oriente, Talca, VII Región, Chile
- B
Parada de Autobus Talca Varoli
Rho 1131, Talca, VII Región, Chile - C
Parada de Autobus Talca Cruce Varoli
Veintiuno Ote 253, Talca, VII Región, Chile - D
Estación de Ferrocarriles de Talca
Once Ote 900-1002, Talca, VII Región, Chile - E
Terminal Tur Bus de Talca
Trece Ote 851-889, Talca, VII Región, Chile - F
Cruce Sur San Javier
Sgto Aldea 2456, San Javier, VII Región, Chile
Stops in La Serena
- AAmunátegui 107, La Serena, Región de Coquimbo, Chile
- B
Rotonda La Serena
Panamericana Norte 208, La Serena, Región de Coquimbo, Chile
Compare bus companies
Based on 11556 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the WiFi. FlixBus ticket prices on this trip start at $25
Frequently asked questions about travelling from Talca to La Serena, CL by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Talca to La Serena?
The cheapest bus tickets from Talca to La Serena start from $25. The average price for this route is around $35. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Talca to La Serena?
The average bus travel time from Talca to La Serena is 11h, covering a distance of 617 km. The quickest bus can get you there in 10h 40m and is operated by FlixBus.
Which bus companies service the Talca to La Serena route?
Several major bus companies operate on this route with 4 buses available per day.
What are the earliest and latest departure times for the bus from Talca to La Serena?
The earliest bus departs from Talca to La Serena at 6:40am. And the latest bus departs at 5:45pm.
What are the CO₂ emissions for the bus trip from Talca to La Serena?
A bus trip from Talca to La Serena generates an estimated 15 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Talca to La Serena, CL was searched and found on Dec 13, 2025 with a price of $30To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Talca to La Serena, CL, as early as possible.
You can expect to pay from $30 to $38 for a bus ticket from Talca to La Serena, CL based on the last 2 days. You can expect to find the cheapest price for the trip at $30 which is on 2025-12-13.
