Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Tampa Bus Station | Lake City Bus Station | Cheapest | ||||
 | Bus | Tampa Bus Station | Lake City Bus Station | Fastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Tampa Bus Station | Lake City Bus Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | University of South Florida | Lake City Bus Station | No tags |
Last refresh of the prices: Yesterday at 8:17 PM EST.
Get from Tampa to Lake City
The journey takes about 10 hours 25 minutes, and with fares starting at just $44, it presents an excellent value for a comfortable ride.
Where are the popular stops in Tampa and Lake City?
Stops in Tampa
- A
Tampa 13th Avenue Bus Stop (McDonald's)
2101 E 13th Ave (McDonald's), Tampa, FL 33605 - B
Tampa USF, FL
3801 USF Holly Drive, Tampa., FL 33620, USA - C
Greyhound Station
610 E Polk St, Tampa, FL 33602, USA - D
E Sligh Ave
11555 E Sligh Ave, Seffner, FL 33584, USA - E
N Marion St & E Laurel St
551 E Laurel St, Tampa, FL 33602, USA - F
Port of Tampa
200-298 FL-60, Tampa, FL 33602, USA
Stops in Lake City
- A2470 W US HWY 90, Lake City, FL 32025, USA
- B
Lake City Greyhound Bus Station
251 S MARION AVE , 32055, Florida
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Frequently asked questions about travelling from Tampa to Lake City by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Tampa to Lake City?
The cheapest bus tickets from Tampa to Lake City start from $44. The average price for this route is around $78. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Tampa to Lake City?
The average bus travel time from Tampa to Lake City is 10h 25m, covering a distance of 249 km. The quickest bus can get you there in 7h and is operated by FlixBus.
Which bus companies service the Tampa to Lake City route?
What are the earliest and latest departure times for the bus from Tampa to Lake City?
The earliest bus departs from Tampa to Lake City at 6:20am. And the latest bus departs at 10:35pm.
What are the CO₂ emissions for the bus trip from Tampa to Lake City?
A bus trip from Tampa to Lake City generates an estimated 6 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Tampa to Lake City?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 11380 reviews.
Which bus company has the best Wi-Fi from Tampa to Lake City?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Tampa to Lake City?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Tampa to Lake City?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Tampa to Lake City was searched and found on Dec 4, 2025 with a price of $64To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tampa to Lake City, as early as possible.
You can expect to pay from $64 to $134 for a bus ticket from Tampa to Lake City based on the last 2 days. You can expect to find the cheapest price for the trip at $64 which is on 2025-12-04.
