How much is the train ticket from Buffalo to St. Louis?

The cheapest train tickets from Buffalo to St. Louis start at $243. The average price for this train route is around $360. Busbud recommends booking your tickets in advance to increase your chances of getting the lowest possible price.

How long is the train ride from Buffalo to St. Louis?

The average train trip from Buffalo to St. Louis takes 19h 28m and covers 1077 km. The quickest train gets you there in 19h 28m and is operated by Amtrak .

Which train operators serve the Buffalo to St. Louis route?

Several major train operators serve this route, with 1 trains available per day.

What are the earliest and latest departure times for the train from Buffalo to St. Louis?

The earliest train from Buffalo to St. Louis departs at 12:39am. The latest train departs at 12:39am.

Train Buffalo to St. Louis from $143 | Refundable Tickets

Next train departures

Next departures for Buffalo to St. Louis on December 17
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Train	12:39am	Depew Station	1d	12:09am	Gateway Station	Cheapest
Train	12:39am	Depew Station	19h 28m	7:07pm	Gateway Station	Fastest
Train	12:39am	Depew Station	19h 28m	7:07pm	Gateway Station	No tags
Train	12:39am	Depew Station	1d	12:09am	Gateway Station	No tags
Train	12:39am	Depew Station	1d	12:09am	Gateway Station	No tags

Next departures for Buffalo to St. Louis on December 20
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Train	12:39am	Depew Station	1d	12:09am	Gateway Station	Cheapest
Train	12:39am	Depew Station	19h 28m	7:07pm	Gateway Station	Fastest
Train	12:39am	Depew Station	19h 28m	7:07pm	Gateway Station	No tags
Train	12:39am	Depew Station	1d	12:09am	Gateway Station	No tags
Train	12:39am	Depew Station	1d	12:09am	Gateway Station	No tags

Last refresh of the prices: Yesterday at 11:39 AM EST.

Compare 2 ways to go from Buffalo to St. Louis

We recommend taking the train

Among the sustainable travel choices, the train stands out as a good way to reach St. Louis. The journey takes about 19 hours 28 minutes, and with fares starting at just $243, it presents an excellent value for a comfortable ride.

1train per day

19h 28mAverage Duration

1077 kmDistance

98kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$200 - $493	Average Duration1d 10h	CO₂ emissions 27kg CO₂e
Train	Average Price$243 - $1,470	Average Duration19h 28m	CO₂ emissions 98kg CO₂e

Where are the popular train stations and stops in Buffalo, NY and St. Louis?

Buffalo, NY

A
Exchange Street Station
75 Exchange St, Buffalo, NY 14203, USA
Visit page

St. Louis

A
Gateway Station
430 S 15th St, St Louis, MO 63103
Visit page

Train companies

Amtrak

4/55,646 reviews

Staff4.7

Timeliness3.8

Cleanliness4.6

Wifi3.6

Based on 5646 reviews, the company was rated 4.1 stars on Busbud. Travellers were especially satisfied with the seats and the ticket access but often complained with the WiFi. Amtrak ticket prices on this trip start at $243

US train and bus companies:Amtrak, Trenitalia, Renfe, VIA Rail Canada, Amtrak Acela, NS Nederlandse Spoorwegen, Iryo

Frequently asked questions about travelling from Buffalo, NY to St. Louis by train

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the train ticket from Buffalo to St. Louis?
The cheapest train tickets from Buffalo to St. Louis start at $243. The average price for this train route is around $360. Busbud recommends booking your tickets in advance to increase your chances of getting the lowest possible price.
How long is the train ride from Buffalo to St. Louis?
The average train trip from Buffalo to St. Louis takes 19h 28m and covers 1077 km. The quickest train gets you there in 19h 28m and is operated by Amtrak.
Which train operators serve the Buffalo to St. Louis route?
Several major train operators serve this route, with 1 trains available per day.
What are the earliest and latest departure times for the train from Buffalo to St. Louis?
The earliest train from Buffalo to St. Louis departs at 12:39am. The latest train departs at 12:39am.

Find cheapest prices for trains

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

12-12

No data

12-13

No data

Today

$143

12-15

No data

12-16

No data

12-17

$276

12-18

No data

12-19

No data

The cheapest trip from Buffalo, NY to St. Louis was searched and found on Dec 14, 2025 with a price of $143

To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Buffalo, NY to St. Louis, as early as possible.

You can expect to pay from $143 to $1,365 for a train ticket from Buffalo, NY to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $276 which is on 2025-12-17.