Next train departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Train | Depew Station | Gateway Station | Cheapest | ||||
| Train | Depew Station | Gateway Station | Fastest | ||||
| Train | Depew Station | Gateway Station | No tags | ||||
| Train | Depew Station | Gateway Station | No tags | ||||
| Train | Depew Station | Gateway Station | No tags |
Last refresh of the prices: Yesterday at 11:39 AM EST.
Compare 2 ways to go from Buffalo to St. Louis
Among the sustainable travel choices, the train stands out as the good way to reach St. Louis. The journey takes about 19 hours 28 minutes and with fares starting at just $172, it presents an excellent value for a comfortable ride.
Where are the popular train stations and stops in Buffalo, NY and St. Louis?
Train Companies
Based on 5645 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the seats and the ticket access but often complained with the wifi. Amtrak ticket prices on this trip start at $172
Frequently asked questions about traveling from Buffalo, NY to St. Louis by train
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the train ticket from Buffalo to St. Louis?
The cheapest train tickets from Buffalo to St. Louis start from $172. The average price for this train route is around $255. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the train journey from Buffalo to St. Louis?
The average train ride duration from Buffalo to St. Louis is 19h 28m, covering a distance of 668 miles (1077 km). The quickest train can get you there in 19h 28m and is operated by Amtrak.
Which train operators service the Buffalo to St. Louis route?
Several major train operators operate on this route with 1 trains available per day.
What is the earliest and latest departure time for the train from Buffalo to St. Louis?
The earliest train departs from Buffalo to St. Louis at 12:39am. And the latest train departs at 12:39am.
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Buffalo, NY to St. Louis was searched and found on Dec 14, 2025 with a price of $101To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Buffalo, NY to St. Louis, as early as possible.
You can expect to pay from $101 to $967 for a train ticket from Buffalo, NY to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $195 which is on 2025-12-17.
