Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Gare routière de Gerland | Santander (Estacion de Autobuses) | CheapestFastest | ||||
 | Bus | Gare routière de Gerland | Calle Navas de Tolosa, 2 | No tags | ||||
| Bus | Aéroport LYS | Santander (Estacion de Autobuses) | No tags | ||||
| Bus | Gare routière de Gerland | Calle Navas de Tolosa, 2 | No tags |
Last refresh of the prices: Last Friday at 18:26 CEST.
Get from Lyon to Santander
The journey takes about 20 hours, and with fares starting at just PEN 219, it presents an excellent value for a comfortable ride.
Where are the popular stops in Lyon and Santander?
Stops in Lyon
- ARue de Esplanade, 69002 Lyon, France
- C
Lyon
8 Rue de la Paix, 69700 Givors, France - D
Quai de Saoune
4 Cours de Verdun Rambaud, 69002 Lyon, France - E
Villeurbanne INSA
20 Avenue Albert Einstein, 69100 Villeurbanne, France - FLes Charrières, 69570 Dardilly, France
Stops in Santander
- ACalle Navas de Tolosa, 2, 39002 Santander, Cantabria, Spain
- C
Av. de los Castros 43A
Av. de los Castros 43A, 39005 Santander, Cantabria, Spain - D
Calle Camarreal-Ojaiz
Calle Camarreal-Ojaiz, 52, 39011 Santander, Cantabria, Spain - E
Av. de Pontejos
Av. de Pontejos, 33A, 39005 Santander, Cantabria, Spain - F
Estación Marítima
39002 Santander, Cantabria, Spain
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Frequently asked questions about travelling by bus from Lyon to Santander
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Lyon to Santander?
The cheapest coach tickets from Lyon to Santander start from PEN 219. The average price for this route is around PEN 520. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Lyon to Santander?
The average bus journey time from Lyon to Santander is 20h, covering a distance of 453 miles. The fastest bus can take you there in 17h 30m and is operated by FlixBus.
Which bus companies service the Lyon to Santander route?
What is the earliest and latest departure time for the bus from Lyon to Santander?
The earliest bus departs from Lyon to Santander at 05:15. And the latest bus departs at 17:55.
What are the CO₂ emissions for the bus trip from Lyon to Santander?
A bus journey from Lyon to Santander produces an estimated 18.245775000000002 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Which is the best bus company from Lyon to Santander?
According to Busbud customers, the highest-rated bus company on this route is ALSA, with an average rating of 4.3 out of 5 stars based on 61718 reviews.
Which company has the best Wi-Fi from Lyon to Santander?
Based on Busbud reviews, the bus company ALSA has the best Wi-Fi rating with a score of 3.5.
Which bus company offers the most punctual service from Lyon to Santander?
According to Busbud traveller reviews, the most punctual bus company on this route is ALSA, with a punctuality rating of 4.3 out of 5 stars.
Which bus company has the cleanest buses from Lyon to Santander?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is ALSA, with a cleanliness rating of 4.7 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Lyon to Santander was searched and found on 5 May 2026 with a price of PEN 214To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Lyon to Santander as early as possible.
You can expect to pay from PEN 214 to PEN 844 for a bus ticket from Lyon to Santander based on the last 2 days. You can expect to find the cheapest price for the trip at PEN 214, which is on 2026-05-05.
