Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Mesa Bus Stop | Downtown Transit Center | Cheapest | ||||
 | Bus | Mesa Bus Stop | Indianapolis Bus Station | Fastest | ||||
| Bus | Mesa Bus Stop | Indianapolis Bus Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Mesa Bus Stop | Downtown Transit Center | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Mesa Bus Stop | Indianapolis Northeast | No tags |
Last refresh of the prices: Today at 11:02 MST.
Get from Mesa to Indianapolis
The journey takes about 1 day, 21 hours 45 minutes, and with fares starting at just £228, it presents an excellent value for a comfortable ride.
Where are the popular stops in Mesa and Indianapolis?
Stops in Mesa
- A
Mesa Bus Station
1423 S Country Club , Mesa, AZ 85210, USA
Compare bus companies
Based on 87456 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. Greyhound ticket prices on this trip start at £228
Frequently asked questions about travelling by bus from Mesa to Indianapolis
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Mesa to Indianapolis?
The cheapest coach tickets from Mesa to Indianapolis start from £228. The average price for this route is around £269. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Mesa to Indianapolis?
The average bus journey time from Mesa to Indianapolis is 1d 21h, covering a distance of 1483 miles. The fastest bus can take you there in 1d 15h and is operated by Greyhound.
Which bus companies service the Mesa to Indianapolis route?
Several major bus companies operate on this route with 5 buses available per day.
What is the earliest and latest departure time for the bus from Mesa to Indianapolis?
The earliest bus departs from Mesa to Indianapolis at 08:40. And the latest bus departs at 21:10.
What are the CO₂ emissions for the bus trip from Mesa to Indianapolis?
A bus journey from Mesa to Indianapolis produces an estimated 60 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Mesa to Indianapolis was searched and found on 29 Dec 2025 with a price of £184To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Mesa to Indianapolis as early as possible.
You can expect to pay from £184 to £316 for a bus ticket from Mesa to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at £184, which is on 2025-12-29.
