Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Tupelo (Brothers Quick Stop) | Chicago 95Th & Dan Ryan | Cheapest | ||||
 | Bus | Tupelo (Brothers Quick Stop) | Downtown Greyhound Station | Fastest | ||||
| Bus | Tupelo (Brothers Quick Stop) | Downtown Greyhound Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Tupelo (Brothers Quick Stop) | Downtown Greyhound Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Tupelo (Brothers Quick Stop) | Downtown Greyhound Station | No tags |
Last refresh of the prices: Yesterday at 17:23 CST.
Get from Tupelo to Chicago
The journey takes about 1 day, 35 minutes, and with fares starting at just £79, it presents an excellent value for a comfortable ride.
Compare bus companies
Based on 87412 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. Greyhound ticket prices on this trip start at £87
Frequently asked questions about travelling by bus from Tupelo to Chicago
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Tupelo to Chicago?
The cheapest coach tickets from Tupelo to Chicago start from £79. The average price for this route is around £120. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Tupelo to Chicago?
The average bus journey time from Tupelo to Chicago is 1d , covering a distance of 520 miles. The fastest bus can take you there in 17h 40m and is operated by Greyhound.
Which bus companies service the Tupelo to Chicago route?
Several major bus companies operate on this route with 11 buses available per day.
What is the earliest and latest departure time for the bus from Tupelo to Chicago?
The earliest bus departs from Tupelo to Chicago at 05:35. And the latest bus departs at 23:15.
What are the CO₂ emissions for the bus trip from Tupelo to Chicago?
A bus journey from Tupelo to Chicago produces an estimated 21 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Tupelo to Chicago was searched and found on 4 Dec 2025 with a price of £96To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tupelo to Chicago as early as possible.
You can expect to pay from £96 to £310 for a bus ticket from Tupelo to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at £96, which is on 2025-12-04.
