Bus Tickets from Tupelo to Chicago

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TodayJul 16
TomorrowJul 17
from US$110
FriJul 18
SatJul 19
from US$133
SunJul 20
from US$133
MonJul 21
from US$114
TueJul 22
WedJul 23

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: July 17 at
    Departure city: Tupelo
    Departure location: Tupelo (Brothers Quick Stop)
    Arrival time: July 17 at
    Destination city: Chicago
    Destination location: Chicago 95Th & Dan Ryan
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: July 17 at
    Departure city: Tupelo
    Departure location: Tupelo (Brothers Quick Stop)
    Arrival time: July 17 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: July 17 at
    Departure city: Tupelo
    Departure location: Tupelo (Brothers Quick Stop)
    Arrival time: July 18 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: July 17 at
    Departure city: Tupelo
    Departure location: Tupelo (Brothers Quick Stop)
    Arrival time: July 18 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: July 17 at
    Departure city: Tupelo
    Departure location: Tupelo (Brothers Quick Stop)
    Arrival time: July 18 at
    Destination city: Chicago
    Destination location: 537-517 W. Jackson Blvd
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

Last refresh of the prices: Last Thursday at 11:01 PM CDT.

Prices and availability are subject to change.

Accepted payments

  • Visa
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  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Tupelo to Chicago: Trip Overview

Average Ticket PriceUS$148
Average Bus Trip Duration22h 45m
Number of daily buses10
Earliest bus departure5:35am
Distance838 km
Latest bus departure11:15pm

Tupelo to Chicago Bus

With Busbud, comparing and booking tickets for a bus from Tupelo to Chicago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Tupelo to Chicago from the most reliable bus companies operating this trip.

Discover how much the bus trip from Tupelo to Chicago will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Tupelo - Chicago

  1. How far is Tupelo from Chicago?

    It's about 853 km (529 miles) from Tupelo to Chicago.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
07-14
No data
07-15
No data
Today
No data
07-17
US$123
07-18
No data
07-19
US$132
07-20
US$141
07-21
US$113
busbud logoThe cheapest trip from Tupelo to Chicago was searched and found on Jul 21, 2025 with a price of US$113

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tupelo to Chicago, as early as possible.

You can expect to pay from US$113 to US$173 for a bus ticket from Tupelo to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at US$113 which is on 2025-07-21.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Tupelo to Chicago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Tupelo to Chicago, get comfy and count the stars.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Tupelo to Chicago will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Tupelo to Chicago.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to Tupelo by bus?

Bus from Tupelo to Chicago

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