Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Tupelo (Brothers Quick Stop) | Chicago 95Th & Dan Ryan | Cheapest | ||||
 | Bus | Tupelo (Brothers Quick Stop) | Downtown Greyhound Station | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Tupelo (Brothers Quick Stop) | Downtown Greyhound Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Tupelo (Brothers Quick Stop) | Chicago 95Th & Dan Ryan | No tags |
Last refresh of the prices: Yesterday at 9:10 PM CDT.
Get from Tupelo to Chicago
The journey takes about 1 day, 10 minutes, and with fares starting at just COP 345,165, it presents an excellent value for a comfortable ride.
Compare bus companies
Based on 87557 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi‑Fi. Greyhound ticket prices on this trip start at COP 364,166
Frequently asked questions about travelling from Tupelo to Chicago by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Tupelo to Chicago?
The cheapest bus tickets from Tupelo to Chicago start from COP 345,165. The average price for this route is around COP 447,972. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Tupelo to Chicago?
The average bus travel time from Tupelo to Chicago is 1d , covering a distance of 848 km. The quickest bus can get you there in 17h 30m and is operated by Greyhound.
Which bus companies service the Tupelo to Chicago route?
Several major bus companies operate on this route with 10 buses available per day.
What are the earliest and latest departure times for the bus from Tupelo to Chicago?
The earliest bus departs from Tupelo to Chicago at 5:35am. And the latest bus departs at 11:15pm.
What are the CO₂ emissions for the bus trip from Tupelo to Chicago?
A bus trip from Tupelo to Chicago generates an estimated 21.1901 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Tupelo to Chicago was searched and found on May 27, 2026 with a price of COP 365,422To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tupelo to Chicago, as early as possible.
You can expect to pay from COP 365,422 to COP 1,142,186 for a bus ticket from Tupelo to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at COP 365,422 which is on 2026-05-27.
