Bus Tickets from Tupelo to Chicago

Next departures

Next departures for Tupelo to Chicago on October 6
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc. + FlixBus
Tupelo (Brothers Quick Stop)
Chicago 95Th & Dan RyanCheapest
Greyhound Lines, Inc. + FlixBus
Tupelo (Brothers Quick Stop)
Chicago 95Th & Dan RyanFastest
Greyhound Lines, Inc. + FlixBus
Tupelo (Brothers Quick Stop)
Downtown Greyhound StationNo tags
Greyhound Lines, Inc.
Tupelo (Brothers Quick Stop)
Downtown Greyhound StationNo tags
Greyhound Lines, Inc. + FlixBus
Tupelo (Brothers Quick Stop)
Downtown Greyhound StationNo tags

Last refresh of the prices: Yesterday at 8:45 AM CDT.

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Tupelo to Chicago: Trip Overview

Average ticket price$124
Average bus trip duration23h 5m
Number of daily buses10
Earliest bus departure5:35am
Distance520 miles (838 km)
Latest bus departure11:15pm

Tupelo to Chicago Bus

With Busbud, comparing and booking tickets for a bus from Tupelo to Chicago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Tupelo to Chicago from the most reliable bus companies operating this trip.

Discover how much the bus trip from Tupelo to Chicago will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip Tupelo - Chicago

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10/03
$142
10/04
No data
Today
$135
10/06
$116
10/07
No data
10/08
$109
10/09
$116
10/10
No data
busbud logoThe cheapest trip from Tupelo to Chicago was searched and found on Oct 8, 2025 with a price of $109

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tupelo to Chicago, as early as possible.

You can expect to pay from $109 to $255 for a bus ticket from Tupelo to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $109 which is on 2025-10-08.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Tupelo to Chicago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Tupelo to Chicago, get comfy and count the stars.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Tupelo to Chicago will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Tupelo to Chicago.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to Tupelo by bus?

Bus from Chicago to Tupelo

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