Next departures from Prague to Brussels on 24 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Prague (Na Knížecí)
Brussels North Train Station
Cheapest
Bus
Prague (Na Knížecí)
Brussels North Train Station
Fastest
Bus
Prague (Main Railway Station)
Brussels Airport
No tags
Bus
Prague (Main Railway Station)
Brussels Airport
No tags
Bus
Prague (Main Station - parking)
Brussels Airport
No tags
Next departures from Prague to Brussels on 25 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Florenc
Brussels South (Gare du Midi)
CheapestFastest
Next departures from Prague to Brussels on 27 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Florenc
Brussels-South (Gare du Midi)
CheapestFastest
Next departures from Prague to Brussels on 28 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Florenc
Brussels South (Gare du Midi)
CheapestFastest
Last refresh of the prices: Today at 17:47 CET.
Compare 2 ways to travel from Prague to Brussels
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as a good way to reach Brussels. The journey takes about 18 hours 40 minutes and with fares starting at just £35, it presents an excellent value for a comfortable ride.
Based on 11414 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the Wi-Fi. FlixBus ticket prices on this trip start at £38
Based on 11150 reviews, the company was rated 3.7 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the Wi-Fi. BlaBlaCar Bus ticket prices on this trip start at £52
Based on 1057 reviews, the company was rated 4.1 stars on Busbud. Travellers were especially satisfied with the departure location and the value for money but often complained with the Wi-Fi. RegioJet ticket prices on this trip start at £35
Frequently asked questions about travelling by bus from Prague to Brussels
How far is Brussels from Prague by coach?
The journey from Prague to Brussels by coach covers an approximate distance of 446 miles (719 km).
What is the best way to go from Prague to Brussels without flying?
To travel from Prague to Brussels without flying, you can take the coaches. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You might also find carpooling options to travel between the two cities.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
21/11
£37
22/11
No data
Today
£66
24/11
£45
25/11
£37
26/11
No data
27/11
£60
28/11
£47
The cheapest trip from Prague to Brussels was searched and found on 21 Nov 2025 with a price of £37
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Prague to Brussels as early as possible.
You can expect to pay from £37 to £134 for a bus ticket from Prague to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at £37, which is on 2025-11-25.
What's the cheapest way to go from Prague to Brussels?
The bus is the cheapest travel choice for this destination