Next bus departures

Next departures from Prague to Brussels on 30 July
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	10:35	Prague (Central Bus Station Florenc)	13h 20m	23:55	Brussels North Train Station	CheapestFastest
Bus	19:00	Florenc	19h 45m	14:45	Brussels-South (Gare du Midi)	No tags
Bus	07:20	Prague (Central Bus Station Florenc)	22h 5m	05:25	Brussels Airport BRU (Parking P14)	No tags
Bus	16:00	Prague (Central Bus Station Florenc)	17h 25m	09:25	Brussels Airport BRU (Parking P14)	No tags
Bus	18:00	Prague (Central Bus Station Florenc)	18h 30m	12:30	Brussels Airport BRU (Parking P14)	No tags
Bus	20:00	Prague (Central Bus Station Florenc)	16h 40m	12:40	Brussels Airport BRU (Parking P14)	No tags
Bus	23:05	Prague (Central Bus Station Florenc)	17h 45m	16:50	Brussels Airport BRU (Parking P14)	No tags
Bus	15:45	Prague (Main Railway Station)	17h 40m	09:25	Brussels Airport BRU (Parking P14)	No tags

Next departures from Prague to Brussels on 31 July
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	10:35	Prague (Central Bus Station Florenc)	13h 20m	23:55	Brussels North Train Station	Cheapest
Bus	18:00	Florenc	12h	06:00	Brussels South (Gare du Midi)	Fastest
Bus	07:20	Prague (Central Bus Station Florenc)	22h 5m	05:25	Brussels Airport BRU (Parking P14)	No tags
Bus	16:00	Prague (Central Bus Station Florenc)	17h 25m	09:25	Brussels Airport BRU (Parking P14)	No tags
Bus	18:00	Prague (Central Bus Station Florenc)	18h 30m	12:30	Brussels Airport BRU (Parking P14)	No tags
Bus	20:00	Prague (Central Bus Station Florenc)	16h 40m	12:40	Brussels Airport BRU (Parking P14)	No tags
Bus	23:05	Prague (Central Bus Station Florenc)	17h 45m	16:50	Brussels Airport BRU (Parking P14)	No tags
Bus	02:55	Prague (Main Railway Station)	21h 45m	00:40	Brussels Airport BRU (Parking P14)	No tags

Next departures from Prague to Brussels on 1 August
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	03:25	Prague (Main Station - parking)	14h 30m	17:55	Brussels North Train Station	Cheapest
Bus	10:35	Prague (Central Bus Station Florenc)	13h 20m	23:55	Brussels North Train Station	Fastest
Bus	07:20	Prague (Central Bus Station Florenc)	22h 5m	05:25	Brussels Airport BRU (Parking P14)	No tags
Bus	16:00	Prague (Central Bus Station Florenc)	17h 25m	09:25	Brussels Airport BRU (Parking P14)	No tags
Bus	18:00	Prague (Central Bus Station Florenc)	18h 30m	12:30	Brussels Airport BRU (Parking P14)	No tags
Bus	20:00	Prague (Central Bus Station Florenc)	16h 40m	12:40	Brussels Airport BRU (Parking P14)	No tags
Bus	23:05	Prague (Central Bus Station Florenc)	17h 45m	16:50	Brussels Airport BRU (Parking P14)	No tags
Bus	04:00	Prague (Main Railway Station)	20h 40m	00:40	Brussels Airport BRU (Parking P14)	No tags

Next departures from Prague to Brussels on 2 August
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Bus	19:00	Florenc	18h 30m	13:30	Brussels-South (Gare du Midi)	CheapestFastest

Next departures from Prague to Brussels on 3 August
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	22:45	PRG Airport	17h 45m	16:30	Brussels North Train Station	Cheapest
Bus	11:05	Prague (Central Bus Station Florenc)	13h 20m	00:25	Brussels North Train Station	Fastest
Bus	07:20	Prague (Central Bus Station Florenc)	22h 5m	05:25	Brussels Airport BRU (Parking P14)	No tags
Bus	18:00	Prague (Central Bus Station Florenc)	17h 15m	11:15	Brussels Airport BRU (Parking P14)	No tags
Bus	23:05	Prague (Central Bus Station Florenc)	17h 45m	16:50	Brussels Airport BRU (Parking P14)	No tags
Bus	04:00	Prague (Main Railway Station)	22h 5m	02:05	Brussels Airport BRU (Parking P14)	No tags
Bus	05:50	Prague (Main Railway Station)	1d	06:35	Brussels Airport BRU (Parking P14)	No tags
Bus	14:45	Prague (Main Railway Station)	20h 5m	10:50	Brussels Airport BRU (Parking P14)	No tags

Next departures from Prague to Brussels on 4 August
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	23:05	Prague (Central Bus Station Florenc)	14h 50m	13:55	Brussels South (Gare du Midi)	Cheapest
Bus	18:00	Florenc	12h	06:00	Brussels South (Gare du Midi)	Fastest
Bus	07:20	Prague (Central Bus Station Florenc)	22h 5m	05:25	Brussels Airport BRU (Parking P14)	No tags
Bus	18:00	Prague (Central Bus Station Florenc)	17h 15m	11:15	Brussels Airport BRU (Parking P14)	No tags
Bus	23:05	Prague (Central Bus Station Florenc)	17h 45m	16:50	Brussels Airport BRU (Parking P14)	No tags
Bus	03:30	Prague (Main Railway Station)	21h 10m	00:40	Brussels Airport BRU (Parking P14)	No tags
Bus	04:00	Prague (Main Railway Station)	22h 5m	02:05	Brussels Airport BRU (Parking P14)	No tags
Bus	05:50	Prague (Main Railway Station)	1d	06:35	Brussels Airport BRU (Parking P14)	No tags

Last refresh of the prices: Yesterday at 17:26 CEST.

Compare 2 ways to travel from Prague to Brussels

We recommend taking the bus

Among the sustainable travel choices, the Bus stands out as a good way to reach Brussels. The journey takes about 18 hours and with fares starting at just CHF 39, it presents an excellent value for a comfortable ride.

30bus per day

18hAverage duration

442 milesDistance

18kgCO₂ emissions

	Average price	Average duration	CO₂ emissions	Actions
Bus	Average priceCHF 39 - CHF 201	Average duration18h	CO₂ emissions 18kg CO₂e
Train	Average priceCHF 44 - CHF 312	Average duration16h	CO₂ emissions 17kg CO₂e

Bus stations and stops in Prague and Brussels

Stops in Prague

A
Florenc
Křižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic
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B
PRG Airport
Aviatická, 161 08, Praha 6, Czechia
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C
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic
D
Černý Most
Chlumecká, 198 00 Praha 20, Czech Republic
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E
Tomíčkova
Tomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia
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F
Hlavní nádraží
300/8 Wilsonova, 110 00 Praha, Czechia
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Stops in Brussels

A
Brussels South (Gare du Midi)
Rue de France 85, 1060 Saint-Gilles, Belgium
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B
Brux-Nord
Boulevard Simon Bolivar 7, 1030 Schaerbeek, Belgium
Visit page
C
Centrale
Rue de Loxum 5, 1000 Bruxelles, Belgium
D
Congrès
Pachecolaan 5, 1000 Brussel, Belgium
Visit page

Compare companies

FlixBus

3.5/513,104 reviews

Staff4.2

Timeliness4.0

Cleanliness4.1

Wi‑Fi2.7

RegioJet

4.1/51,083 reviews

Staff4.5

Timeliness4.0

Cleanliness4.4

Wi‑Fi3.8

BlaBlaCar Bus

3.7/512,199 reviews

Staff4.3

Timeliness3.7

Cleanliness4.3

Wi‑Fi2.6

BE bus companies:FlixBus, BlaBlaCar Bus, Sindbad, Ecolines, KLR Bus, RegioJet, Agat

Frequently asked questions about travelling by bus from Prague to Brussels

Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.

How much is the bus ticket from Prague to Brussels?
The cheapest coach tickets from Prague to Brussels start from CHF 39. The average price for this route is around CHF 74. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Prague to Brussels?
The average bus journey time from Prague to Brussels is 18h, covering a distance of 442 miles. The fastest bus can take you there in 12h and is operated by RegioJet.
Which bus companies service the Prague to Brussels route?
Several major bus companies operate on this route with 30 buses available per day, including services from FlixBus, RegioJet, BlaBlaCar Bus.
What is the earliest and latest departure time for the bus from Prague to Brussels?
The earliest bus departs from Prague to Brussels at 00:05. And the latest bus departs at 23:50.
What are the CO₂ emissions for the bus trip from Prague to Brussels?
A bus journey from Prague to Brussels produces an estimated 17.8187 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Which is the best bus company from Prague to Brussels?
According to Busbud customers, the highest-rated bus company on this route is RegioJet, with an average rating of 4.1 out of 5 stars based on 1083 reviews.
Which company has the best Wi-Fi from Prague to Brussels?
Based on Busbud reviews, the bus company RegioJet has the best Wi-Fi rating with a score of 3.8.
Which bus company offers the most punctual service from Prague to Brussels?
According to Busbud traveller reviews, the most punctual bus company on this route is RegioJet, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Prague to Brussels?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is RegioJet, with a cleanliness rating of 4.4 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

28/07

CHF 58

29/07

CHF 61

Today

CHF 66

31/07

CHF 68

01/08

CHF 66

02/08

CHF 88

03/08

CHF 53

04/08

CHF 53

The cheapest trip from Prague to Brussels was searched and found on 3 Aug 2026 with a price of CHF 53

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Prague to Brussels as early as possible.

You can expect to pay from CHF 53 to CHF 156 for a bus ticket from Prague to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at CHF 53, which is on 2026-08-03.